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Prediction of lymph node metastasis of esophageal squamous cell carcinoma using a biopsy specimen

Research Project

Project/Area Number 21791301
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

UCHIKADO Yasuto  鹿児島大学, 医学部・歯学部附属病院, 助教 (30464465)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords食道癌 / 免液染色 / 蛋白質 / マイクロアレイ / 免疫染色 / 食道扁平上皮癌 / リンパ節転移予測 / 生検標本 / 免疫組織染色法
Research Abstract

In resected specimen, the protein’s expressions of Osteopontin,or Cytokeratin14, or Statimin proteins were significantly concerned with the lymphatic invasion and lymph node metastasis. Furthermore there was significantly relationship between those protein’s expressions and lymph node metastasis in biopsy specimen. Ep-cam, and ColA71 proteins were significantly concerned with the tumor invasion and lymph node metastasis in resected specimen. However, in biopsy specimens, these was no association with clinicopathological factors.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (28 results)

  • [Journal Article] Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer2011

    • Author(s)
      Uchikado Yasuto, Okumura H, Ishigami S, Setoyama T, Matsumoto M, Owaki T, Kita Y, Natsugoe S
    • Journal Title

      Gastric cancer

      Volume: 14 Pages: 41-49

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腹部食道癌に対する手術2011

    • Author(s)
      内門泰斗,松本正隆,奥村 浩,大脇哲洋,夏越祥次
    • Journal Title

      日本臨床

      Volume: 69 Pages: 310-315

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Clinicopathological Significance of BMP7 Expression in Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Megumi K, Ishigami S, Uchikado Yasuto,Kita Y, Okumura H, Matsumoto M, Uenosono Y, Arigami T, Kijima Y, Kitazono M, Shinchi H, Ueno S, Natsugoe S
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Pages: 2066-2071

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of BMP-7 in human gastric cancer and its clinical significance2011

    • Author(s)
      Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Yasuto, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S
    • Journal Title

      Br J Cancer

      Volume: 104 Pages: 714-718

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Significance of BMP7 Expression in Esophageal Squamous Cell Carcinoma2011

    • Author(s)
      Megumi K, Ishigami S, Uchikado Yasuto
    • Journal Title

      Ann Surg Oncol

      Volume: (電子書籍)(Online First) Issue: 6 Pages: 2066-2071

    • DOI

      10.1245/s10434-011-2024-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer.2011

    • Author(s)
      Uchikado Yasuto
    • Journal Title

      Gastric cancer

      Volume: 14 Pages: 41-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 食道癌手術-困難症例・偶発症対処の秘策- 再建胃管血流不良2010

    • Author(s)
      内門泰斗,奥村浩,松本正隆,大脇哲洋,喜多芳昭,夏越祥次
    • Journal Title

      手術

      Volume: 64 Pages: 955-958

    • Related Report
      2012 Final Research Report
  • [Journal Article] 特集食道癌手術-困難症例・偶発症対処の秘策-再建胃管血流不良2010

    • Author(s)
      内門泰斗
    • Journal Title

      手術

      Volume: 64 Pages: 955-958

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 消化器癌の診断・治療 胸部食道癌2009

    • Author(s)
      内門泰斗
    • Journal Title

      治療の実際.消化器外科

      Volume: 32 Pages: 699-705

    • Related Report
      2012 Final Research Report
  • [Journal Article] 消化器癌の診断・治療胸部食道癌治療の実際2009

    • Author(s)
      内門泰斗
    • Journal Title

      消化器外科 32

      Pages: 699-705

    • Related Report
      2009 Annual Research Report
  • [Presentation] 壁深達度MM/SM1のcN0食道表在癌に対する内視鏡的切除にSentinel node navigationを臨床応用した治療戦略2012

    • Author(s)
      内門泰斗,奥村浩,上之園芳一,有上貴明,大脇哲洋,喜多芳昭,佐々木健,松本正隆,瀬戸山徹郎,石神純也,新地洋之,上野真一,夏越祥次
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Endoscopic treatment with sentinel node dissection for superficial esophageal cancer2012

    • Author(s)
      Yasuto Uchikado, Yoshikazu Uenosono, Hiroshi Okumura, Masataka Matsumoto, Tetsuhiro Owaki, Yoshiaki Kita, Ken Sasaki, Takaki Arigami, Takahiko Hagihara, Daisuke Matsushita, Sumiya Ishigami and Shoji Natsugoe
    • Organizer
      13th World Congress of the International Society for Diseases of the Esophagus
    • Place of Presentation
      Venice, Italia
    • Year and Date
      2012-10-16
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 当科における頚部食道癌に対する治療2012

    • Author(s)
      内門泰斗,奥村浩,大脇哲洋,佐々木健,喜多芳昭,松本正隆,尾本至,石神純也,上野真一,夏越祥次
    • Organizer
      第67回日本消化器外科学会総会,富山県民会館
    • Place of Presentation
      富山市
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] MM以深のcN0食道表在癌に対するSentinel node navigationを用いた内視鏡治療2012

    • Author(s)
      内門泰斗,松本正隆,奥村 浩,大脇哲洋,喜多芳昭,佐々木健,尾本 至,橋口照人,石神純也,夏越祥次
    • Organizer
      第66回日本食道学会学術集会
    • Place of Presentation
      軽井沢プリンスホテルウエスト,軽井沢
    • Year and Date
      2012-06-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌と同時性重複癌の治療についての検討2012

    • Author(s)
      内門泰斗,奥村 浩,松本正隆,喜多芳昭,大脇哲洋,尾本 至,佐々木 健,瀬戸山徹郎,有上貴明,上之園芳一,石神純也,新地洋之,上野真一,,夏越祥次
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ,千葉市
    • Year and Date
      2012-04-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌と同時性重複癌の治療についての検討2012

    • Author(s)
      内門泰斗
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ,千葉市
    • Related Report
      2012 Annual Research Report
  • [Presentation] MM以深のcN0食道表在癌に対するSentinel node navigationを用いた内視鏡治療2012

    • Author(s)
      内門泰斗
    • Organizer
      第66回日本食道学会学術集会
    • Place of Presentation
      軽井沢プリンスホテルウエスト,軽井沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] 当科における頚部食道癌に対する治療2012

    • Author(s)
      内門泰斗
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山県民会館,富山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 壁深達度MM/SM1のcN0食道表在癌に対する内視鏡的切除にSentinel node navigationを臨床応用した治療戦略2012

    • Author(s)
      内門泰斗
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル,東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道癌と他臓器の同時性重複癌の検討2011

    • Author(s)
      内門泰斗,松本正隆,奥村 浩,大脇哲洋,喜多芳昭,瀬戸山徹郎,尾本 至,佐々木 健,桜井俊秀,有上貴明,上之園芳一,石神純也,上野真一,夏越祥次
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場 愛知県
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 食道癌と他臓器の同時性重複癌の検討2011

    • Author(s)
      内門泰斗
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場愛知県
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increased Slug and Decreased E-cadherin Expression Is Related to Poor Prognosis in Patients with Gastric Cancer2011

    • Author(s)
      Yasuto Uchikado, Hiroshi Okumura, Sumiya Ishigami, Masataka Matsumoto, Tetsuro Setoyama, Tetsuhiro Owaki, Yoshiaki Kita, Itaru Omoto, Takaaki Arigami, Yoshikazu Uenosono, Shinichi Ueno and Shoji Natsugoe
    • Organizer
      8th International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center 大阪府
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased Slug and Decreased E-cadherin Expression Is Related to Poor Prognosis in Patients with Gastric Cancer2011

    • Author(s)
      Yasuto Uchikado
    • Organizer
      8^<th> International Symposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center大阪府
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 上部消化管癌患者の血清中N型糖鎖による新規腫瘍マーカーの可能性2011

    • Author(s)
      内門泰斗,松本正隆,奥村 浩,喜多芳昭,大脇哲洋,瀬戸山徹郎,尾本 至,有上貴明,上之園芳一,石神純也,新地洋之,上野真一,橋口照人,夏越祥次
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場 愛知県
    • Year and Date
      2011-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 上部消化管癌患者の血清中N型糖鎖による新規腫瘍マーカーの可能性2011

    • Author(s)
      内門泰斗
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場愛知県
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道癌の新規腫瘍マーカーとしての血清中N型糖鎖プロファイリング2011

    • Author(s)
      内門泰斗,松本正隆,奥村 浩,喜多芳昭,大脇哲洋,瀬戸山徹郎,尾本 至,有上貴明,上之園芳一,石神純也,新地洋之,上野真一,夏越祥次
    • Organizer
      第111回日本外科学会定期学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学放射線療法後の食道狭窄に対する食道バイパス術の一工夫2010

    • Author(s)
      内門泰斗,松本正隆,喜多芳昭,大脇哲洋,原口尚士,奥村浩,瀬戸山徹郎,尾本至,桜井俊英,佐々木健,石神純也,上野真一,夏越祥次
    • Organizer
      第72回日本臨床外科学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-11-23
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 当科における進行・再発食道癌の気道狭窄に対する治療2010

    • Author(s)
      内門泰斗,柳 正和,大塚剛志,松本正隆,喜多芳昭,大脇哲洋,奥村 浩,瀬戸山徹郎,尾本 至,佐々木健,桜井俊秀,石神純也,上野真一,夏越祥次
    • Organizer
      第62回日本気管食道科学会総会
    • Place of Presentation
      大分県別府市
    • Year and Date
      2010-11-05
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 食道癌術中,頚胸境界部の気管膜様部損傷に対して胸鎖乳突筋弁被覆を行った一例2010

    • Author(s)
      内門泰斗,松本正隆,奥村浩,大脇哲洋,喜多芳昭,瀬戸山徹郎,佐々木健,尾本至,櫻井俊秀,石神純也,新地洋之,上野真一,夏越祥次
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 透析未導入の慢性腎不全食道癌患者に対するLow dose Docetaxel/5FUによる根治的化学放射線療法の検討2010

    • Author(s)
      内門泰斗,松本正隆,奥村浩,大脇哲洋,喜多芳昭,瀬戸山徹郎,佐々木健,尾本至,櫻井俊秀,石神純也,新地洋之,上野真一,夏越祥次
    • Organizer
      第8回日本消化器外科学会大会(JDDW2010)
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-10-15
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] A relationship between the Snail and Slug expression and prognosis in esophageal squamous cell carcinoma2010

    • Author(s)
      Yasuto Uchikado, Masataka Matsumoto,Hiroshi Okumura, Tetsuro Setoyama, Yoshiaki Kita, Ken Sasaki, Toshihide Sakurai, Itaru Omoto, Tetsuhiro Owaki, Sumiya Ishigami, Shinichi Ueno, and Shoji Natsugoe
    • Organizer
      ISDE 2010
    • Place of Presentation
      Kagoshima city
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] A relationship between the Snail and Slug expression and prognosis in esophageal squamous cell carcinoma.2010

    • Author(s)
      内門泰斗
    • Organizer
      ISDE 2010
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 頚部食道癌に対する治療戦略 -当科における治療成績から-2010

    • Author(s)
      内門泰斗,松本正隆,奥村浩,大脇哲洋,喜多芳昭,瀬戸山徹郎,佐々木健,尾本至,石神純也,夏越祥次
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      福岡県久留米市
    • Year and Date
      2010-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 頚部食道癌に対する治療戦略-当科における治療成績から-2010

    • Author(s)
      内門泰斗
    • Organizer
      第64回日本食道学会学術集会
    • Place of Presentation
      福岡県久留米市
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科における食道切除後の胃管再建法の工夫による縫合不全の改善2010

    • Author(s)
      内門泰斗,松本正隆,奥村浩,瀬戸山徹郎,大脇哲洋,喜多芳昭,石神純也,上野真一,夏越祥次
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2010-07-14
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 乳癌切除後放射線照射後の誘発食道癌切除症例の検討2009

    • Author(s)
      内門泰斗
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-22
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] 進行食道癌の術前補助療法とリンパ節微小転移2009

    • Author(s)
      内門泰斗
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      阪国際会議場
    • Year and Date
      2009-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行食道癌の術前補助療法とリンパ節微小転移2009

    • Author(s)
      内門泰斗
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-07-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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