Development of evaluation and treatment of marginal donor lungs and deceased donor lungs.
Project/Area Number |
21791320
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Thoracic surgery
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Research Institution | Kyoto University |
Principal Investigator |
CHEN Fengshi Kyoto University, 医学研究科, 助教 (00452334)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | マージナルドナー肺 / 心臓死ドナー肺 / 肺移植 / ドナー / マージナルドナー / 心臓死ドナ / 体外回路 |
Research Abstract |
To encounter the donor shortage in lung transplantation, marginal donor lungs and donor lungs after cardiac death have recently been utilized. It would be very important to evaluate such donor lungs before lung transplantation objectively for the safe use of these organs. Thus, the principle investigator established a model, by which the quality of the donor lungs could be assessed, using middle to large animal ex vivo lung perfusion (EVLP) circuit. Furthermore, we demonstrated the results in which EVLP itself could probably resuscitate the marginal donor lungs and donor lungs after cardiac death. From now on, we will accumulate more data regarding EVLP to pursue its possibility and also try to treat the injured donor lungs by administering several drugs during EVLP.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Normothermic ex vivo lung perfusion in clinical lung transplantation.2011
Author(s)
Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S.
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Journal Title
N Engl J Med. 364(15)
Pages: 1431-1440
Related Report
Peer Reviewed
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[Journal Article] Initial experience with lung donation after cardiocirculatory death in Canada.2009
Author(s)
Cypel M, Sato M, Yildirim E, Karolak W, Chen F, Yeung J, Boasquevisque C, Leist V, Singer LG, Yasufuku K, DePerrot M, Waddell TK, Keshavjee S, Pierre A.
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Journal Title
J Heart Lung Transplant 28
Pages: 753-758
Related Report
Peer Reviewed
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[Presentation] Challenge in size matching in pediatric single lobar lung transplantation using three-dimensional computed tomographic volumetry.2011
Author(s)
Chen F, Ishii H, Shoji T, Fujinaga T, Sonobe M, Ikeda T, Nakata T, Nakajima D, Sakamoto J, Osumi A, Sakai H, Bando T, Kubo T, Date H.
Organizer
30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#702
Place of Presentation
San Diego
Related Report
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[Presentation] Reconditioning of lungs from non-heart-beating donors with normothermic ex vivo lung perfusion.2011
Author(s)
Nakajima D, Yamada T, Chen F, Sakamoto J, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
Organizer
30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#91
Place of Presentation
San Diego
Related Report
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[Presentation] Reconditioning of lungs with pulmonary edema in ex vivo lung perfusion circuit.2011
Author(s)
Yamada T, Nakajima D, Sakamoto J, Chen F, Okamoto T, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
Organizer
30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#422
Place of Presentation
San Diego
Related Report
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[Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung2010
Author(s)
Sakamoto J, Yamada T, Chen F, Nakajima D, Kikuchi R, Kojima F, Osumi A, Takahashi A, Satoda N, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
Organizer
transplantation model.O11.04 XXIII International Congress of The Transplantation Society Vancouver
Place of Presentation
Canada
Related Report
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[Presentation] Ex vivo lung perfusion in clinical lung transplantation-The "HELP" trial.2010
Author(s)
Cypel M, Yeung JC, de Perrot M, Karolak W, Chen F, Sato M, Azad S, Madonik M, Hutcheon M, Chaparro C, Chow CW, Yasufuku K, Pierre A, Singer LG, Waddell TK, Keshavjee S.
Organizer
30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #258
Place of Presentation
Chicago
Related Report
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[Presentation] Novel surgical training system of lung transplantation in continuous pulmonary perfusion and ventilation using pig heart-lung blocks.2010
Author(s)
Okamoto T, Yamada T, Morikawa H, Nakayama E, Satoda N, Zhang J, Takahashi A, Zhao X, Chen F, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
Organizer
30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #430
Place of Presentation
Chicago
Related Report
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[Presentation] 心臓死ドナーからの肺移植:トロント大学における経験2009
Author(s)
陳豊史、Marcelo Cypel, Wojtek Karolak, Shaf Keshavjee, Andrew Pierre, 板東徹、伊達洋至
Organizer
第62回日本胸部外科学会定期学術集会,O-149
Place of Presentation
横浜
Year and Date
2009-10-13
Related Report
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