Development of evaluation and treatment of marginal donor lungs and deceased donor lungs.

• Project/Area Number: 21791320
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kyoto University
• Principal Investigator: CHEN Fengshi Kyoto University, 医学研究科, 助教 (00452334)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: マージナルドナー肺 / 心臓死ドナー肺 / 肺移植 / ドナー / マージナルドナー / 心臓死ドナ / 体外回路

Research Abstract

To encounter the donor shortage in lung transplantation, marginal donor lungs and donor lungs after cardiac death have recently been utilized. It would be very important to evaluate such donor lungs before lung transplantation objectively for the safe use of these organs. Thus, the principle investigator established a model, by which the quality of the donor lungs could be assessed, using middle to large animal ex vivo lung perfusion (EVLP) circuit. Furthermore, we demonstrated the results in which EVLP itself could probably resuscitate the marginal donor lungs and donor lungs after cardiac death. From now on, we will accumulate more data regarding EVLP to pursue its possibility and also try to treat the injured donor lungs by administering several drugs during EVLP.

Research Products

• [Journal Article] Normothermic ex vivo lung perfusion in clinical lung transplantation. (2011)
  • Author(s): Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S.
  • Journal Title: N Engl J Med. 364(15) Pages: 1431-1440
  • Peer Reviewed
• [Journal Article] Comparison of ET-Kyoto solution and Perfadex solution in apig ex vivo lung perfusion model : Impact of potassium level. (2011)
  • Author(s): Okamoto T, Chen F, et al.
  • Journal Title: Transplantation Proceedings Volume: (In press)
  • Peer Reviewed
• [Journal Article] Safety of normothermic ex vivo lung perfusion in clinical lung transplantation. (2011)
  • Author(s): Cypel M, Chen F, et al.
  • Journal Title: N Eng J Med Volume: (In press)
  • Peer Reviewed
• [Journal Article] Establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs. (2010)
  • Author(s): Okamoto T, Chen F, Zhang J, Yamada T, Nakayama E, Morikawa H, Bando T, Date H.
  • Journal Title: Transplant Proc 42(5) Pages: 1598-1601
  • Peer Reviewed
• [Journal Article] Comparison of ET-Kyoto solution and Perfadex solution in a pig ex vivo lung perfusion model : Impact of potassium level. (2010)
  • Author(s): OkamotoT, Chen F, Zhang J, Choi H, Yamada T, Morikawa H, Nakayama E, Bando T, Date H.
  • Journal Title: Organ Transplant. 15 Pages: 2-2
  • Peer Reviewed
• [Journal Article] Establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs. (2010)
  • Author(s): Okamoto T, Chen F, et al.
  • Journal Title: Transplantation Proceedings Volume: 42 Pages: 1598-1601
  • Peer Reviewed
• [Journal Article] Initial experience with lung donation after cardiocirculatory death in Canada. (2009)
  • Author(s): Cypel M, Sato M, Yildirim E, Karolak W, Chen F, Yeung J, Boasquevisque C, Leist V, Singer LG, Yasufuku K, DePerrot M, Waddell TK, Keshavjee S, Pierre A.
  • Journal Title: J Heart Lung Transplant 28 Pages: 753-758
  • Peer Reviewed
• [Journal Article] 肺移植の最前線:新しいドナーソースからの肺移植-心臓死ドナーを中心としたマージナルドナーからの肺移植- (2009)
  • Author(s): 陳豊史、伊達洋至
  • Journal Title: 移植 44 Pages: 415-420
  • NAID: 10026246670
• [Journal Article] Initial experience with lung donation after cardiocirculatory death in Canada. (2009)
  • Author(s): Cypel M, Chen F, Keshavjee S, et al.
  • Journal Title: J Heart Lung Transplant 28 Pages: 753-758
  • Peer Reviewed
• [Journal Article] The establishment of an ex-vivo lung perfusion model using non-heart-beating large pigs.
  • Author(s): Okamoto T, Chen F, Zhang J, et al.
  • Journal Title: Transplant Proc (In press)
  • Peer Reviewed
• [Presentation] 常温肺体外灌流一normothermic ex-vo lung perfusion (EVLP)一による心停止ドナー肺の回復 (2011)
  • Author(s): 中島大輔、山田徹、陳豊史、阪本仁、大角明宏、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 第27回肺および心肺移植研究会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-01-29
• [Presentation] 常温肺体外灌流一normothermic ex-vo lung perfusion (EVLP)一による心停止ドナー肺の回復。 (2011)
  • Author(s): 中島大輔、陳豊史、山田徹、阪本仁、大角明宏、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 第28回日本呼吸器外科学会総会,O06-04
  • Place of Presentation: 大分
• [Presentation] Challenge in size matching in pediatric single lobar lung transplantation using three-dimensional computed tomographic volumetry. (2011)
  • Author(s): Chen F, Ishii H, Shoji T, Fujinaga T, Sonobe M, Ikeda T, Nakata T, Nakajima D, Sakamoto J, Osumi A, Sakai H, Bando T, Kubo T, Date H.
  • Organizer: 30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#702
  • Place of Presentation: San Diego
• [Presentation] Reconditioning of lungs from non-heart-beating donors with normothermic ex vivo lung perfusion. (2011)
  • Author(s): Nakajima D, Yamada T, Chen F, Sakamoto J, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
  • Organizer: 30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#91
  • Place of Presentation: San Diego
• [Presentation] Reconditioning of lungs with pulmonary edema in ex vivo lung perfusion circuit. (2011)
  • Author(s): Yamada T, Nakajima D, Sakamoto J, Chen F, Okamoto T, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
  • Organizer: 30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract#422
  • Place of Presentation: San Diego
• [Presentation] イヌ心停止ドナー肺移植モデルにおける臓器摘出前の換気によるグラフト肺保護効果 (2010)
  • Author(s): 阪本仁、山田徹、陳豊史、中島大輔、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 第46回日本移植学会総会,045
  • Place of Presentation: 京都
  • Year and Date: 2010-10-22
• [Presentation] Intermediate-term outcomes of the living donor lobar lung transplantation following hematopoietic stem cell transplantation from the same donor. (2010)
  • Author(s): Chen F, et al.
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: Vancouver
  • Year and Date: 2010-08-19
• [Presentation] Hypothermic ex vivo perfusion prevents ischemia reperfusion injury in rat lungs from non-heart-beating donors. (2010)
  • Author(s): Nakajima D, Chen F, et al.
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: Vancouver
  • Year and Date: 2010-08-15
• [Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung transplantation model. (2010)
  • Author(s): Sakamoto J, Chen F, et al.
  • Organizer: XXIII International Congress of The Transplantation Society
  • Place of Presentation: Vancouver
  • Year and Date: 2010-08-15
• [Presentation] 中動物肺移植モデルを用いた、摘出前換気による心停止ドナー肺の保護効果 (2010)
  • Author(s): 阪本仁、山田徹、陳豊史、中島大輔、菊地柳太郎、小島史嗣、大角明宏、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 第63回日本胸部外科学会定期学術集会,OP-07
  • Place of Presentation: 大阪
• [Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung (2010)
  • Author(s): Sakamoto J, Yamada T, Chen F, Nakajima D, Kikuchi R, Kojima F, Osumi A, Takahashi A, Satoda N, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
  • Organizer: transplantation model.O11.04 XXIII International Congress of The Transplantation Society Vancouver
  • Place of Presentation: Canada
• [Presentation] Ex vivo lung perfusion in clinical lung transplantation-The "HELP" trial. (2010)
  • Author(s): Cypel M, Yeung JC, de Perrot M, Karolak W, Chen F, Sato M, Azad S, Madonik M, Hutcheon M, Chaparro C, Chow CW, Yasufuku K, Pierre A, Singer LG, Waddell TK, Keshavjee S.
  • Organizer: 30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #258
  • Place of Presentation: Chicago
• [Presentation] 長時間常温体外循環(Ex vivo lung perfusion)の確立 (2010)
  • Author(s): 中島大輔、山田徹、阪本仁、陳豊史、岡本俊宏、張吉天、高橋鮎子、里田直樹、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 日本呼吸器外科学会総会,P017-05
  • Place of Presentation: 仙台
• [Presentation] Novel surgical training system of lung transplantation in continuous pulmonary perfusion and ventilation using pig heart-lung blocks. (2010)
  • Author(s): Okamoto T, Yamada T, Morikawa H, Nakayama E, Satoda N, Zhang J, Takahashi A, Zhao X, Chen F, Fujinaga T, Shoji T, Sakai H, Bando T, Date H.
  • Organizer: 30th Annual Meeting of the International Society for Heart and Lung Transplantation, Abstract #430
  • Place of Presentation: Chicago
• [Presentation] 心臓死ドナーからの肺移植:トロント大学における経験 (2009)
  • Author(s): 陳豊史、Marcelo Cypel, Wojtek Karolak, Shaf Keshavjee, Andrew Pierre, 板東徹、伊達洋至
  • Organizer: 第62回日本胸部外科学会定期学術集会,O-149
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-13
• [Presentation] 心臓死ドナーからの肺移植:トロント大学における経験 (2009)
  • Author(s): 陳豊史
  • Organizer: 第62回日本胸部外科学会定期学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-13
• [Presentation] 肺移植Clinical fellowを通して感じたこと。 (2009)
  • Author(s): 陳豊史
  • Organizer: 第62回日本胸部外科学会定期学術集会,W1-5
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-11
• [Presentation] マージナルドナー肺心臓死ドナー肺の新しい評価と保護法。 (2009)
  • Author(s): 陳豊史、岡本俊宏、山田徹、張吉天、青山晃博、藤永卓司、森川洋匡、高橋鮎子、里田直樹、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 第45回日本移植学会総会,S5-3
  • Place of Presentation: 東京
  • Year and Date: 2009-09-18
• [Presentation] How the cause of death affects the quality of DCD donor lung?-An experimental study- (2009)
  • Author(s): T.Yamada, F.Chen, et al.
  • Organizer: 29th Annual Meeting of the International Society for Heart and Lung Transplantation
  • Place of Presentation: Paris France
• [Presentation] Normothermic human ex vivo lung perfusion (EVLP) for improved assessment of extended criteria donor lungs for transplantation (2009)
  • Author(s): Cypel M, Chen F, Keshavjee S, et al.
  • Organizer: 29th Annual Meeting of the International Society for Heart and Lung Transplantation
  • Place of Presentation: Paris France
• [Book] -心臓死ドナーを中心としたマージナルドナーからの肺移植-(肺移植の最前線:新しいドナーソースからの肺移植)(移植)(44) (2009)
  • Author(s): 陳豊史、伊達洋至
  • Publisher: へるす出版
• [Remarks] ホームページ等
  • URL: http://www.thoracic-kyoto-u.gr.jp/
• [Remarks]
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• [Remarks]
  • URL: http://www.thoracic-kyoto-u.gr.jp/