Evaluation of lung injury by non-heat-heating donor in rats.

• Project/Area Number: 21791321
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kyoto University
• Principal Investigator: YAMADA Tetsu Kyoto University, 医学研究科, 研究協力員 (90534347)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 心停止ドナー / 肺移植 / 肺障害

Research Abstract

Considering the difference in introduction of cardiac arrest cardiac arrest donors, Flush rat lung experiments that aim to promote the use of donor lung evaluation and clinical response to the background. Were able to determine the characteristics and differences in lung injury due to cardiac arrest by the introduction of experimental conditions. Next, we analyzed the physiological function of rat lungs after ischemia-re-circulating extracorporeal circulation using a rat model. In the late reperfusion pulmonary vascular resistance was higher than in the group confirmed that the apnea group and the heart beat a group of VF. The findings will lead to the establishment of the evaluation according to the clinical background of the donor lung.

Research Products

• [Presentation] 心ビーグル犬を用いた長時間肺体外循環Ex vivo lung perfusion (EVLP)回路の確立 (2010)
  • Author(s): 山田徹、陳豊史、阪本仁、中島大輔、里田直樹、高橋鮎子、園部誠、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 日本心肺移植研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-01-30
• [Presentation] Injury of Donor Lungs from Donation after Cardiac Death in Various Settings; Investigation by RT-PCR and Pathology. (2010)
  • Author(s): T.Yamada, F.Chen, J.Sakamoto, D.Nakajima, N.Satoda, A.Takahashi, T.Shoji, T.Fujinaga, H.Sakai, T.Bando, H.Date.
  • Organizer: ISHLT国際心肺移植学会
  • Place of Presentation: シカゴ
• [Presentation] 心停止条件による心停止ドナー肺傷害の検討 (2009)
  • Author(s): 山田徹、陳豊史、阪本仁、中島大輔、里田直樹、高橋鮎子、松本泉、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
  • Organizer: 日本胸部外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-12
• [Presentation] How the cause of death affects the quality of DCD donor lung?-An experimental study. (2009)
  • Author(s): T.Yamada, F.Chen, J.Zhang, T.Okamoto, T.Fujinaga, H.Morikawa, I.Matsumoto, N.Satoda, A.Takahashi, T.Shoji, H.Sakai, T.Bando, H.Date.
  • Organizer: 日本移植学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-18
• [Presentation] 心停止条件の違いによる心停止ドナー肺障害の検討 (2009)
  • Author(s): 山田徹, 他
  • Organizer: 第45回日本移植学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-18
• [Presentation] The International Society for Heart and Lung Transplantation. (2009)
  • Author(s): T.Yamada.
  • Organizer: 29th Annual Meeting and Scientific Sessions.
  • Place of Presentation: Paris
• [Presentation] the 29th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (2009)
  • Author(s): T.Yamada., et.all
  • Organizer: the 29th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantatinn
  • Place of Presentation: Paris, France
• [Presentation] 心臓死ドナー肺における心停止導入条件と肺傷害RT・PCRと病理的検討 (2009)
  • Author(s): 山田徹, 他
  • Organizer: 第62回日本胸部外科学会総会
  • Place of Presentation: 横浜
• [Remarks] ホームページ等
  • URL: http://www.thoracic-kyoto-u.gr.jp/
• [Remarks]
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