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Evaluation of lung injury by non-heat-heating donor in rats.

Research Project

Project/Area Number 21791321
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKyoto University

Principal Investigator

YAMADA Tetsu  Kyoto University, 医学研究科, 研究協力員 (90534347)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords心停止ドナー / 肺移植 / 肺障害
Research Abstract

Considering the difference in introduction of cardiac arrest cardiac arrest donors, Flush rat lung experiments that aim to promote the use of donor lung evaluation and clinical response to the background. Were able to determine the characteristics and differences in lung injury due to cardiac arrest by the introduction of experimental conditions. Next, we analyzed the physiological function of rat lungs after ischemia-re-circulating extracorporeal circulation using a rat model. In the late reperfusion pulmonary vascular resistance was higher than in the group confirmed that the apnea group and the heart beat a group of VF. The findings will lead to the establishment of the evaluation according to the clinical background of the donor lung.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 Other

All Presentation (8 results) Remarks (3 results)

  • [Presentation] 心ビーグル犬を用いた長時間肺体外循環Ex vivo lung perfusion (EVLP)回路の確立2010

    • Author(s)
      山田徹、陳豊史、阪本仁、中島大輔、里田直樹、高橋鮎子、園部誠、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      日本心肺移植研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Injury of Donor Lungs from Donation after Cardiac Death in Various Settings; Investigation by RT-PCR and Pathology.2010

    • Author(s)
      T.Yamada, F.Chen, J.Sakamoto, D.Nakajima, N.Satoda, A.Takahashi, T.Shoji, T.Fujinaga, H.Sakai, T.Bando, H.Date.
    • Organizer
      ISHLT国際心肺移植学会
    • Place of Presentation
      シカゴ
    • Related Report
      2010 Final Research Report
  • [Presentation] 心停止条件による心停止ドナー肺傷害の検討2009

    • Author(s)
      山田徹、陳豊史、阪本仁、中島大輔、里田直樹、高橋鮎子、松本泉、藤永卓司、庄司剛、阪井宏彰、板東徹、伊達洋至
    • Organizer
      日本胸部外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] How the cause of death affects the quality of DCD donor lung?-An experimental study.2009

    • Author(s)
      T.Yamada, F.Chen, J.Zhang, T.Okamoto, T.Fujinaga, H.Morikawa, I.Matsumoto, N.Satoda, A.Takahashi, T.Shoji, H.Sakai, T.Bando, H.Date.
    • Organizer
      日本移植学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 心停止条件の違いによる心停止ドナー肺障害の検討2009

    • Author(s)
      山田徹, 他
    • Organizer
      第45回日本移植学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] The International Society for Heart and Lung Transplantation.2009

    • Author(s)
      T.Yamada.
    • Organizer
      29th Annual Meeting and Scientific Sessions.
    • Place of Presentation
      Paris
    • Related Report
      2010 Final Research Report
  • [Presentation] the 29th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation2009

    • Author(s)
      T.Yamada., et.all
    • Organizer
      the 29th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantatinn
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓死ドナー肺における心停止導入条件と肺傷害RT・PCRと病理的検討2009

    • Author(s)
      山田徹, 他
    • Organizer
      第62回日本胸部外科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.thoracic-kyoto-u.gr.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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