The experimental research on the artificial bioabsorbable trachea

• Project/Area Number: 21791327
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kagawa University
• Principal Investigator: CHANG Sunsoo Kagawa University, 医学部附属病院, 助教 (00419508)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 気管軟骨 / b-FGF / BMP-2 / 組織再生 / 生体吸収性材料

Research Abstract

The purpose of this research is a replacement of canine cervical trachea by the artificial bioabsorbable trachea with slow releasing cell growth factor. Optimum dose of cell growth factor (b-FGF : basic fibroblast growth factor, BMP-2 : bone morphogenetic protein) was 100μg, respectively. Two-third of the cervical trachea replacement model with the use of a bioabsorbable poly-L-lactic acid and ε-caprolactone copolymer (PLAC) scaffold and slow releasing cell growth factor survived for 4 weeks without marked airway stenosis, cartilage regeneration was not revealed histologically.