| Project/Area Number |
21791328
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Kochi University |
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Principal Investigator |
YAMAMOTO Masaki 高知大学, 教育研究部・医療学系, 助教 (20437718)
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| Research Collaborator |
YAMAGUCHI Tokio 東京医科歯科大学, 難治疾患研究所, 准教授
SATO Takayuki 高知大学, 教育研究部・医療学系, 教授
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 心臓大血管外科学 / 心筋虚血再還流障害 / 酸化ストレス / 虚血性心疾患 / 心筋虚血再灌流 / バイオピリン / 酸化ビリルビン / Methylpredonizolone |
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| Research Abstract |
Reduced organ blood flow causes deficient oxygen and energy supply to the tissue, resulting in necrosis such as angina pectoris and myocardial infarction. Restoring blood flow and re-oxygenation improves metabolism in the ischemic myocardium, thus salvaging the heart. At the same time, reperfusion to the ischemic tissue can also cause ischemia/ reperfusion injury. Tissue damage from reactive oxygen species(ROS) has been suggested as a mechanism of ischemia reperfusion injury. In this study, we used oxidative bilirubin with an antioxidant component, to investigate oxidative stress dynamics and mechanisms.
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