Cardiac tissue engineering by 3D-culture in collagen hydrogel

Research Project

Project/Area Number	21791329
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Nara Medical University
Principal Investigator	NAITO Hiroshi Nara Medical University, 医学部, 助教 (00316069)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	心臓大血管外科学 / 再生医療 / 組織工学 / 心筋再生 / 人工心筋組織
Research Abstract	The optimum culture conditions (type of collagens, with or without use of Matrigel) for constructing artificial three-dimensional cardiac tissue were evaluated. The condition of using home-made collagen and Matrigel was found to have properties similar to the artificial myocardial tissue which have been reported. However, the problems of small contraction force and poor responsiveness to calcium are remaining. It still needs to optimize culture conditions in addition to collagen and Matrigel.

Report

(3 results)