Cardiac tissue engineering by 3D-culture in collagen hydrogel
| Project/Area Number |
21791329
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
NAITO Hiroshi Nara Medical University, 医学部, 助教 (00316069)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 心臓大血管外科学 / 再生医療 / 組織工学 / 心筋再生 / 人工心筋組織 |
|---|
| Research Abstract |
The optimum culture conditions (type of collagens, with or without use of Matrigel) for constructing artificial three-dimensional cardiac tissue were evaluated. The condition of using home-made collagen and Matrigel was found to have properties similar to the artificial myocardial tissue which have been reported. However, the problems of small contraction force and poor responsiveness to calcium are remaining. It still needs to optimize culture conditions in addition to collagen and Matrigel.
|
Report
(3 results)
Research Products
(4 results)
