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Vagal denervation in the surgery for atrial fibrillation : Identification of cardiac autonomic nerural network

Research Project

Project/Area Number 21791335
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNippon Medical School

Principal Investigator

SAKAMOTO Shunichiro  日本医科大学, 医学部, 助教 (50398872)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心臓神経叢 / 心房細動手術 / 心臓神経叢(GP) / GPネットワーク / active GP / dominant GP / 心房細動 / 自律神経 / 不整脈 / 外科
Research Abstract

High frequency stimulation was applied to 5 anatomical ganglionated plexi(GP) areas, a total of 35 sites to identify the active GP with marked vagal reflex(prolongation of ventricular interval by more than 50%). Active GP was observed in the right pulmonary vein, left pulmonary vein, inferior left atrium and left atrial roof. Right pulmonary vein is the most frequent seen active GP area. Epicardial ablation of active GP provided complete vagal denervation in terms of eliminating electrical activities in the whole atrium and additional endocardial ablation for the remaining network was not required. Sequential pacing and ablation technique identify the epicardial GP network with a dominant active GP. The GP in the inferior left atrium was the most dominant active GP in the atrium. Active GP in the medial-cranial and medial-caudal area was more comparatively dominant than lateral area in the network.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Presentation (8 results)

  • [Presentation] 心房細動手術における心臓神経叢(GP)ネットワーク同定と除神経効果についての検討2012

    • Author(s)
      坂本俊一郎, 他
    • Organizer
      第42回日本心臓血管外科学会総会
    • Place of Presentation
      秋田
    • Year and Date
      2012-04-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Ablation of the Ganglionated Plexi(GP) combined with the Radial Procedure using Sequential Pacing and Ablation Technique : Clinical Experience and Outcomes at Short. and Mid-term Follow-up.2011

    • Author(s)
      坂本俊一郎, 他
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Ablation of the Ganglionated Plexi (GP) combined with the Radial Procedure using Sequential Pacing and Ablation Technique : Clinical Experience and Outcomes at Short-and Mid-term Follow-up2011

    • Author(s)
      坂本俊一郎
    • Organizer
      第64回日本胸部外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Short-and Mid-term Outcome of Combined Ganglionated Plexi(GP) Ablation and Radial Procedure for the Treatment of Atrial Fibrillation.2011

    • Author(s)
      坂本俊一郎, 他
    • Organizer
      4th Asia Pacific Heart Rhythm Society Scientific session
    • Place of Presentation
      福岡
    • Year and Date
      2011-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Short- and Mid-term Outcome of Combined Ganglionated Plexi (GP) Ablation and Radial Procedure for the Treatment of Atrial Fibrillation2011

    • Author(s)
      坂本俊一郎
    • Organizer
      4^<th> Asia Pacific Heart Rhythm Society Scientific session
    • Place of Presentation
      ヒルトン福岡
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心臓神経叢(GP : Ganglionated Plexi)アブレーション2011

    • Author(s)
      坂本俊一郎
    • Organizer
      第25回不整脈外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 心臓神経叢(GP : Ganglionated Plexi)アブレーション2011

    • Author(s)
      坂本俊一郎
    • Organizer
      不整脈外科研究会
    • Place of Presentation
      東京ベイ舞浜ホテル
    • Year and Date
      2011-02-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Surgical ablation of cardiac ganglionated plexi (GP) : vagal modification and treatment for atrial fibrillation2010

    • Author(s)
      坂本俊一郎
    • Organizer
      第36回日本胸部外科学会postgraduate course
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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