Gene expression profiles associated with neurocognitive decline after aortic surgery under deep hypothermic circulatory arrest.

• Project/Area Number: 21791337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Osaka Medical College
• Principal Investigator: MIENO Shigetoshi Osaka Medical College, 医学部, 助教 (10411373)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心臓大血管外科 / 大動脈瘤 / 大動脈手術 / 高次機能障害

Research Abstract

This study was examined incidence of temporary neurocognitive decline (NCD) and change in gene expression associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest. Neurocognitive decline (NCD) occurred at 60% after the aortic surgery. The change in gene expression between pre-and post-operative blood sample was compared by microarray analysis. Change in the gene expression involved in inflammatory and immune responses was associated with NCD after aortic surgery utilizing deep hypothermic circulatory arrest.

Research Products

• [Journal Article] Minimizing cerebral embolism in resection of distal aortic arch aneurysm through a left thoracotomy. (2011)
  • Author(s): Mieno S., Ozawa H., Daimon M., Woo C., Sasaki T., Katsumata T.
  • Journal Title: Ann Thorac Surg. 91 Pages: 472-477
• [Journal Article] A surgical case of excision of infected aneurysm arising from anterior interosseal artery following infectious endocarditis. (2011)
  • Author(s): Mieno S., Ozawa H, Tanigawa J, Kurisu Y, Katsumata T.
  • Journal Title: J Vase Surg. 53 Pages: 1104-1106
• [Journal Article] Kommerell憩室に対する外科治療経験 (2011)
  • Author(s): 三重野繁敏, 小澤英樹、大門雅広、佐々木智康、禺英喜、勝間田敬弘
  • Journal Title: 日本心臓血管学会雑誌
  • NAID: 130004548325
• [Journal Article] Minimizing cerebral embolism in resection of distal aortic arch aneurysm through a left thoracotomy. (2011)
  • Author(s): Mieno S.
  • Journal Title: Ann Thorac Surg. Volume: 91 Pages: 472-477
  • Peer Reviewed
• [Journal Article] A surgical case of excision of infected aneurysm arising from anterior interosseal artery following infectious endocarditis. (2011)
  • Author(s): Mieno S.
  • Journal Title: J Vasc Surg Volume: 53 Pages: 1104-1106
  • Peer Reviewed
• [Journal Article] Kommerell憩室に対する外科治療経験 (2011)
  • Author(s): 三重野繋敏
  • Journal Title: 日本心臓血管学会雑誌 Volume: (In press)
  • NAID: 130004548325
  • Peer Reviewed
• [Journal Article] Ascending aortic injury caused by a fractured sternal wire 28 years after surgical intervention of pectus excavatum. (2010)
  • Author(s): Mieno S, Ozawa H, Katsumata T.
  • Journal Title: J Thorac Cardiovasc Surg. 140(1) Pages: 18-20
• [Journal Article] Ascending aortic injury caused by a fractured sternal wire 28 years after surgical intervention of pectus excavatum. (2010)
  • Author(s): Mieno S
  • Journal Title: J Thorac Cardiovasc Surg. Volume: 140
  • Peer Reviewed
• [Presentation] Shaggy Aorta を伴う胸部下行.胸腹部大動脈瘤に対する外科治療成績 (2010)
  • Author(s): 大門雅広、三重野繁敏, ら
  • Organizer: 第38回日本血管外科学会学術総会
  • Place of Presentation: さいたま市
  • Year and Date: 2010-05-20
• [Presentation] Shaggy Aortaを伴う胸部下行・胸腹部大動脈瘤に対する外科治療成績 (2010)
  • Author(s): 大門雅広
  • Organizer: 第38回日本血管外科学会学術総会
  • Place of Presentation: さいたま市