Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Research Abstract |
To evaluate prion removal efficacy of many disinfectants, multi-round PMCA was applied. We then analysed several sets of serial 10-fold dilutions of mock-treated samples statistically, and found that PMCA round numbers linearly correlate with means of dilution factors of infected brain between the second and sixth round. We found that a combined use of alkaline cleaner and autoclaving (121℃, 15min) was one of the most effective treatments for prion inactivation, and the log reduction factor of PrP^<res> was estimated to be ≧7log.
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