| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We focused on pathophysiological states of carotid atherosclerotic lesion as one of targets of cerebral ischemia. Our purposes were first, evaluation of expression of lectin-like low density lipoprotein receptor 1 (LOX1) in rat carotid plaque, second, establishment of targeting drug delivery system for carotid atherosclerotic lesion using LOX1. Liposomal fasudil conjugated with anti-LOX1 antibody on the surface was newly developed and selective accumulation of the new drug and effectiveness on inhibition of abrogation of carotid plaque. The new liposomal fasudil was specifically accumulated on the carotid lesion and plaque extension was significantly inhibited after intravenous administration of liposomal fasudil with LOX1 antibody.
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