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The monitoring of autophagy in human brain tumor samples and pathological analysis

Research Project

Project/Area Number 21791350
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNiigata University

Principal Investigator

NATSUMEDA Manabu  新潟大学, 脳研究所, 非常勤講師 (00515728)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsオートファジー / 神経膠腫 / テモゾロミド / 抗LC3B抗体 / 免疫染色法 / Western blot法 / 放射線 / オートファジーモニタリング
Research Abstract

The induction of autophagy is effectively monitored in glioma cell cultures. However, the monitoring of autophagy in gliomas has not been established in surgically removed tissues. A new method to monitor autophagy in surgically removed brain tumor tissue employing immunohistochemistry and Western blotting was established, and induction of autophagy was detected after temozolomide treatment.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Induction of autophagy in temozolomide treated malignant gliomas2011

    • Author(s)
      Natsumeda M, Aoki H, Miyahara H, Yajima N, Uzuka T, Toyoshima Y, Kakita A, Takahashi H, Fujii Y
    • Journal Title

      Neuropathology

      Volume: 31(5) Issue: 5 Pages: 486-93

    • DOI

      10.1111/j.1440-1789.2010.01197.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagy in temozolomide treated malignant gliomas.2011

    • Author(s)
      M.Natsumeda, et al.
    • Journal Title

      Neuropathology

      Volume: (Ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pseudoprogression症例におけるMGMT発現及びオートファジー誘導の検討2011

    • Author(s)
      棗田学
    • Organizer
      第29回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Pseudoprogression症例におけるMGMT発現及びオートファジー誘導の検討2011

    • Author(s)
      棗田学
    • Organizer
      第29回日本脳腫瘍病理学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 悪性神経膠腫におけるオートファジーモニタリング2010

    • Author(s)
      棗田学
    • Organizer
      新潟脳神経研究会例会
    • Place of Presentation
      新潟
    • Year and Date
      2010-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性神経膠腫におけるオートファジーモニタリング2010

    • Author(s)
      棗田学
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性神経膠腫症例におけるオートファジーモニタリング2010

    • Author(s)
      棗田学
    • Organizer
      第69回日本脳神経外科学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性神経膠腫症例におけるテモゾロミド治療前後のオートファジーモニタリング2010

    • Author(s)
      棗田学
    • Organizer
      第11回日本分子脳神経外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性神経膠腫におけるオートファジーモニタリング2010

    • Author(s)
      棗田学
    • Organizer
      第40回新潟大学脳研究所夏期セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2010-08-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性神経膠腫症例におけるオートファジーモニタリングと治療抵抗性獲得の検討2010

    • Author(s)
      棗田学
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 悪性神経膠腫症例におけるオートファジーモニタリングと治療抵抗性獲得の検討2010

    • Author(s)
      棗田学
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪((発表確実))
    • Year and Date
      2010-05-22
    • Related Report
      2009 Annual Research Report
  • [Book] The induction of autophagy in gliomas treated by temozolomide2011

    • Author(s)
      Natsumeda M, Aoki H, Fujii Y
    • Publisher
      Nova Science Publishers Inc
    • Related Report
      2011 Final Research Report
  • [Book] The induction of autophagy in gliomas treated by temozolomide. In Autophagy : Principles, Regulation and Roles in Disease2011

    • Author(s)
      Natsumeda M, Aoki H, Fujii Y
    • Total Pages
      16
    • Publisher
      Nova Science Publishers Inc
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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