Cytogenetic analysis and classification of medulloblastoma
Project/Area Number |
21791351
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
|
Research Institution | Kanazawa University |
Principal Investigator |
MISAKI Koichi Kanazawa University, 附属病院, 助教 (20507082)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 髄芽腫 / 分子遺伝学 / 病理学 / catenin / Wnt pathway / 脳腫瘍 / 髄腔内播種 / Wnt signal pathway |
Research Abstract |
We performed pathological classification of primary medulloblastomas and examined molecules on the Wnt signal pathway by immunohistochemical and cytogenetic analyses. Pathologically, three patients were diagnosed with newly established subtype of medulloblastoma. Immunohistochemical cyclin D1 expression showed a trend of adverse outcome and all seven patients with cyclin D1 expression expired. On the contrary, γ-catenin expression correlated with good prognosis among the molecules analyzed. This research contributed to prognostic evaluation of medulloblastomas.
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Report
(3 results)
Research Products
(22 results)