• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell transduced with herpes simplex virus-thymidine kinase gene and ganciclovir

Research Project

Project/Area Number 21791354
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KOIZUMI Shinichiro  Hamamatsu University School of Medicine, 医学部・脳神経外科学, リサーチアシスタント (10456577)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳腫瘍学 / 脳腫瘍 / 遺伝子治療 / iPS細胞 / チミジンキナーゼ
Research Abstract

I studied the bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell (iPS cell) transduced with herpes simplex virus-thymidine kinase gene and ganciclovir, however, it has run into difficulties. So, at first, I examined the migration ability of iPS cells to malignant glioma and tumor-associated specific growth factors in vitro and in vivo. iPS cell show intensive migratory to the malignant gliomas. And tumor-associated growth factors participate in migration. We suggested that iPS cell can become effective vehicles for delivering gene therapies to malignant glioma.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Migration of mouse induced pluripotent stem cells to glioma conditioned medium is mediated by tumor-associated specific growth factors2011

    • Author(s)
      Shinichiro Koizumi
    • Journal Title

      Oncology Letter 2

      Pages: 283-288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Migration of mouse induced pluripotent stem cells to glioma conditioned medium is mediated by tumor-associated specific growth factors2011

    • Author(s)
      Shinichiro Koizumi
    • Journal Title

      Oncology Letter

      Volume: 2 Pages: 283-288

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Migration of mouse induced pluripotent stem cells to glioma conditioned medium is mediated by tumor-associated specific growth factors2010

    • Author(s)
      Shinichiro Koizumi
    • Organizer
      10th Kyungpook Hamamatsu Joint Medical Symposium
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2010-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Migration of mouse induced pluripotent stem cells to glioma conditioned medium is mediated by tumor-associated specific growth factors2010

    • Author(s)
      Shinichiro Koizumi
    • Organizer
      10th Kyungpook-Hamamatsu Joint Medical Symposium
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] in vitro、in vivoにおける悪性神経膠腫へのマウスiPS細胞の移動能の基礎評価2010

    • Author(s)
      小泉慎一郎
    • Organizer
      第28回日本脳腫瘍学会
    • Place of Presentation
      軽井沢
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] マウスiPS細胞における、悪性神経膠腫および成長因子への移動能、特異的指向性の基礎評価2010

    • Author(s)
      小泉慎一郎
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] マウスiPS細胞における悪性神経膠腫、成長因子への移動能の評価2010

    • Author(s)
      小泉慎一郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] マウスiPS細胞における悪性神経膠腫、specific growth factorsへの移動能の基礎評価2010

    • Author(s)
      小泉慎一郎
    • Organizer
      第11回日本分子脳神経外科学会
    • Place of Presentation
      仙台
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi