Study of bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell transduced with herpes simplex virus-thymidine kinase gene and ganciclovir
| Project/Area Number |
21791354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KOIZUMI Shinichiro Hamamatsu University School of Medicine, 医学部・脳神経外科学, リサーチアシスタント (10456577)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳腫瘍学 / 脳腫瘍 / 遺伝子治療 / iPS細胞 / チミジンキナーゼ |
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| Research Abstract |
I studied the bystander effect in the therapy of malignant gliomas by using induced pluripotent stem cell (iPS cell) transduced with herpes simplex virus-thymidine kinase gene and ganciclovir, however, it has run into difficulties. So, at first, I examined the migration ability of iPS cells to malignant glioma and tumor-associated specific growth factors in vitro and in vivo. iPS cell show intensive migratory to the malignant gliomas. And tumor-associated growth factors participate in migration. We suggested that iPS cell can become effective vehicles for delivering gene therapies to malignant glioma.
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Report
(3 results)
Research Products
(8 results)
