| Project/Area Number |
21791359
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
KINOSHITA Manabu Osaka University, 医学系研究科, 助教 (40448064)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 分子イメージング / MRI / Affibody / SPIO / HER-2 |
|---|
| Research Abstract |
Detecting HER-2 expression is clinically relevant, as treatment methods and prognosis differ according to HER-2 expression status. In this study, we have focused on a small molecule named Affibody, which is one-tenth in molecular size of an antibody, possessing equal capability. SPIO was labeled to Affbody for MRI detection. When HER-2 overexpressing tumor (SKOV-3 ovarian cancer cell line) was inoculated to a SCID mouse, Affibody-SPIO successfully imaged HER-2 receptor on MRI. Accumulation of Affibody and SPIO was confirmed on histology.
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