| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
We administrated Erythropoietin (EPO) via intra-ventricular injection to the epileptic model of rats. Compared to the non-treated rats, the EPO-treated rats showed the milder epilepsy severity score and suppression of abnormal neurogenesis in the hippocampus without polycythemia. We continuously administrated low dose of Brain-derived neurotrophic factor (BDNF) to the epileptic model of rats. Compared to the non-treated rats, the BDNF-treated rats showed the milder epilepsy severity score, better survival in the hippocampal pyramidal neurons and more number of immature neuronal differentiated cells. Based on these facts, continuous low dose administration of BDNF can yield neuroprotection and neurogenesis.
|
