Neural stimulus in the deep brain area can enhance hippocampal neurogenesis and regenerate hippocampal neural circuit in the epileptic model of animals
| Project/Area Number |
21791363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
AGARI Takashi Okayama University, 岡山大学病院, 助教 (60423290)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | てんかん / エリスロポイエチン / 神経栄養因子 / 神経新生 / 神経保護 / 神経保護効果 |
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| Research Abstract |
We administrated Erythropoietin (EPO) via intra-ventricular injection to the epileptic model of rats. Compared to the non-treated rats, the EPO-treated rats showed the milder epilepsy severity score and suppression of abnormal neurogenesis in the hippocampus without polycythemia. We continuously administrated low dose of Brain-derived neurotrophic factor (BDNF) to the epileptic model of rats. Compared to the non-treated rats, the BDNF-treated rats showed the milder epilepsy severity score, better survival in the hippocampal pyramidal neurons and more number of immature neuronal differentiated cells. Based on these facts, continuous low dose administration of BDNF can yield neuroprotection and neurogenesis.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats2011
Author(s)
Kuramoto S, Yasuhara T, Agari T, Kondo A, Jing M, Kikuchi Y, Shinko A, Wakamori T, Kameda M, Wang F, Kin K, Edahiro S, Miyoshi Y, Date I.
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Journal Title
Brain Res. 1368(Epub 2010 Nov 18.)
Pages: 281-289
Related Report
Peer Reviewed
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[Journal Article] Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion2010
Author(s)
Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, Kadota T, Baba T, Tajiri N, Wang F, Tayra JT, Liang H, Miyoshi Y, Borlongan CV, Date I
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Journal Title
Journal of Cellular Physiology Oct 13(Epub)
Related Report
Peer Reviewed
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[Journal Article] Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats2009
Author(s)
Kondo A, Shingo T, Yasuhara T, Kuramoto S, Kameda M, Kikuchi Y, Matsui T, Miyoshi Y, Agari T, Borlongan CV, Date I.
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Journal Title
Brain Res 1296
Pages: 127-136
Related Report
Peer Reviewed
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