Effects of mesenchymal stem cell on microenvironment of brain tumor

Research Project

Project/Area Number	21791367
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Kyushu University
Principal Investigator	中溝玲 Kyushu University, 大学院・医学研究院, 講師 (80529800)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	間葉系幹細胞 / 幹細胞 / 脳腫瘍 / 治療 / 病態生理
Research Abstract	We proved that human mesenchymal stem cells accelerate the growth of human glioma cells (U87 cells) by cell-cell contact or unverified liquid factor. The level of VEGF、 bFGF、 TGFβ1、 MMP1、 MMP2、 MMP3、 MMP9、 MMP13、 MMP1、 IL-1β、 IL-8、 IL-10、 IL-13、 CCL3、 CCL-4、 CCL-5 in the supernatant obtained from the co-culture system were measured ELISA assay. We proved that the secretion of MMP2 and MMP3 from human glioma cells are inhibited by the presence of human mesenchymal stem cells in a dose-dependent manner.

Report

(3 results)