Neurogenesis after ischemic brain injury in basal ganglia and thalamus

• Project/Area Number: 21791373
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Yokohama City University
• Principal Investigator: TATEISHI Kensuke Yokohama City University, 医学部, 助教 (00512055)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 全脳虚血モデル / 遅発性神経細胞死 / 神経再生誘導 / 視床 / 線条体 / 脳虚血モデル / 海馬CA1 / 前脳室下帯 / 後脳室下帯 / 内在性神経幹細胞 / 虚血性脳障害 / 局所脳虚血モデル

Research Abstract

We assessed whether the similar neurogenesis was possible in another area of the hippocampal CA1 after the global ischemia . In this reserch, the striatum and thalamic were made in the target. Because the load for the neuronal death was more severe than the hippocampal cell death, we could not completely analyze the neurogenesis of these targets. The problem remained of the viewpoint of the selective cell death and individual living in this research.