Control of intracellular signaling, involved in neuronal differentiation by using protein transduction domain and its application
| Project/Area Number |
21791374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUBO Atsuhiko 横浜市立大学, 医学研究科, 客員研究員 (80525030)
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| Research Collaborator |
KANNO Hiroshi 横浜市立大学, 医学研究科, 客員准教授 (40244496)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 神経分化 / ペプチド / 皮膚由来幹細胞 / パーキンソン病 / STAT3 / VHL / 幹細胞移植 / 膜貫通タンパク / SOCS |
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| Research Abstract |
As central nervous system is not regenerated naturally, reproduce of the damaged brain/neuron is expected by transplant of neuronal stem cells. Topics clarified in this study are 1 ; neuronal differentiation potential of skin-derived precursor cells 2 ; control of an intra-cellular factor involved in neuronal differentiation by using peptide. We identified the skin-derived precursor cells had neuronal differentiation ability and the advantage that there was no necessary of gene manipulation for the cells from isolation to transplant procedure. I designed the peptide, there was little cytotoxicity, which introduced to control intracellular signaling enrolled of neuronal differentiation inducing factor. It was thought that the utilization of the skin-derive precursor cells were useful as exclusive law of the regenerative medicine at this time
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Report
(4 results)
Research Products
(13 results)
