| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
As central nervous system is not regenerated naturally, reproduce of the damaged brain/neuron is expected by transplant of neuronal stem cells. Topics clarified in this study are 1 ; neuronal differentiation potential of skin-derived precursor cells 2 ; control of an intra-cellular factor involved in neuronal differentiation by using peptide. We identified the skin-derived precursor cells had neuronal differentiation ability and the advantage that there was no necessary of gene manipulation for the cells from isolation to transplant procedure. I designed the peptide, there was little cytotoxicity, which introduced to control intracellular signaling enrolled of neuronal differentiation inducing factor. It was thought that the utilization of the skin-derive precursor cells were useful as exclusive law of the regenerative medicine at this time
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