Co-transplantation of ES Cells and Bone Marrow Stromal Cells for Spinal Cord Injury
| Project/Area Number |
21791375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
MATSUDA Ryosuke Nara Medical University, 医学部, 助教 (60453164)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脊髄損傷 / 骨髄間質細胞 / ES細胞 / 共培養 / 共移植 / 脊髄間質細胞 |
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| Research Abstract |
We performed co-transplantation of neural stem cells derived from ES cells and bone marrow stromal cells for spinal cord injury in mice. We checked motor function after spinal cord injury weekly and histopathological examination using neuronal markers. Histopathological examination revealed that neural stem cells derived Es cells differentiated into Nestin positive cells and MAP2 positive cells. There is no significance for motor functional improvement between co-transplantation group and other control groups. The reason for ineffectiveness of this study is unclear. Further study will be required.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Cotransplantation of mouse embryonic Stem cells and bone marrow stromal cells followingspinal cord injury suppresses2009
Author(s)
Matsuda R, Yoshikawa M, Kimura H, Ouji Y, Nakase H, Nishimura F, Nonaka J, Toriumi H, Yamada S, Nishiofuku M, Moriva K, Ishizaka S, Nakamura M, Sakaki T
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Journal Title
Cell transplantation 18
Pages: 39-54
Related Report
Peer Reviewed
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