Identification of novel growth factor for Glioma cancer stem cells
| Project/Area Number |
21791377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
TAKAHASHI Satoshi Keio University, 医学部, 研究員 (20383870)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳腫瘍学 / 腫瘍幹細胞 / 脳腫瘍 / 幹細胞 / 増殖因子 / 神経膠腫 / 脳腫瘍幹細胞 |
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| Research Abstract |
We have conducted our research for the purpose of identifying novel growth factors for glioma cancer stem cells, and identified KIF23 and uPARAP. Downregulation of KIF23 in glioma cells suppressed their proliferation. Downregulation of uPARAP in glioma cells suppressed migration and invasion properties of glioma cells through changes in actin cytoskeleton. We have also confirmed the expressions of the both molecules in glioma cancer stem cells at protein level.
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Report
(3 results)
Research Products
(12 results)
