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The analysis of the angiogenesis and the vasculogenesis in the yellow ligament of the lumbar spine

Research Project

Project/Area Number 21791380
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNippon Medical School

Principal Investigator

KIM Kyongsong  日本医科大学, 医学部, 助教 (30339387)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords黄色靭帯 / 腰椎 / 血管新生 / 血管増生 / 変性 / 低酸素 / 黄色靱帯
Research Abstract

We performed the several staining of the lumbar spine yellow ligament and could observe the degenerative change and neo-vascularization in the yellow ligament. The degenerative change and increasing of the vessels were more severe in the outer part than the inner part. We could detect the HIF, SDF and the VEGF in the degenerative yellow ligament. However, these expressions were low and it has not found the relation of the these expression and degenerative change.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009 Other

All Journal Article (24 results) (of which Peer Reviewed: 13 results)

  • [Journal Article] Cervical Anterior Fusion with the Williams-Isu Method: Clinical Review2012

    • Author(s)
      Kim K, Isu T, Morimoto D, Sugawara A, Kobayashi S, Teramoto A.
    • Journal Title

      Journal of Nippon Medical School

      Volume: 79 Issue: 1 Pages: 37-45

    • DOI

      10.1272/jnms.79.37

    • NAID

      130004147136

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2011 Final Research Report
  • [Journal Article] Cervical anterior fusion with the Williams-Isu method : clnical review2012

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Journal of Nippon Medical School

      Volume: 79 Pages: 37-45

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed Study of Graft Sinking and Worsening of the Fused Segment Angle in Patients With Cervical Disease Treated With the Williams-Isu Method2011

    • Author(s)
      Kim K, Isu T, Sugawara A, Morimoto D, Matsumoto R, Isobe M, Mishina M, Kobayashi S, Teramoto A.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 51 Issue: 3 Pages: 208-213

    • DOI

      10.2176/nmc.51.208

    • NAID

      10029137600

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
  • [Journal Article] Selective Posterior Decompression of the Cervical Spine2011

    • Author(s)
      Kim K, Isu T, Sugawara A, Matsumoto R, Isobe M, Morimoto D, Mishina M, Kobayashi S, Yoshida D, Teramoto A
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 51 Issue: 2 Pages: 108-112

    • DOI

      10.2176/nmc.51.108

    • NAID

      10028104863

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of the Williams-Isu method and the transvertebral approach to treat cervical disease2011

    • Author(s)
      Kim K, Isu T, Sugawara A, Morimoto D, Shimoda Y, Matsumoto R, Isobe M, Mishina M, Kobayashi S, Teramoto A.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 18 Issue: 3 Pages: 396-400

    • DOI

      10.1016/j.jocn.2010.04.052

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Unexplained Lower Abdominal Pain Associated with Sacroiliac Joint Dysfunction: Report of 2 Cases2011

    • Author(s)
      Morimoto D, Isu T, Kim K, Matsumoto R, Isobe M.
    • Journal Title

      Journal of Nippon Medical School

      Volume: 78 Issue: 4 Pages: 257-260

    • DOI

      10.1272/jnms.78.257

    • NAID

      130004147103

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2011 Final Research Report
  • [Journal Article] Posttraumatic Carotid-Cavernous Fistulae Treated by Internal Carotid Artery Trapping and High-Flow Bypass Using a Radial Artery Graft -Two Case Reports-2011

    • Author(s)
      Mizunari T, Murai Y, Kim K, Kobayashi S, Kamiyama H, Teramoto A.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 51 Issue: 2 Pages: 113-116

    • DOI

      10.2176/nmc.51.113

    • NAID

      10028104880

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
  • [Journal Article] Detailed Study of Graft Sinking and Worsening of the Fused Segment Angle in Patients With Cervical Disease Treated With the Williams-Isu Method2011

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Neurologia Medico-Chirurgica

      Volume: 51 Pages: 208-213

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective posterior decompression of the cervical spine2011

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Neurologia Medico-Chirurgica

      Volume: 51 Pages: 108-112

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination of the Williams-Isu method and the transvertebral approach to treat cervical disease.2011

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 18 Pages: 396-400

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed Study of Graft Sinking and Worsening of the Fused Segment Angle in Patients With Cervical Disease Treated With the Williams-Isu Method.2011

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Neurologia Medico-Chirurgica

      Volume: 51 Pages: 208-213

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective posterior decompression of the cervical spine.2011

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Neurologia Medico-Chirurgica

      Volume: 51 Pages: 108-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concomitant Cranial and Lumbar Subdural Hematomas -Case Report-2010

    • Author(s)
      Kim K, Katsuno M, Isu T, Mishina M, Yoshida D, Kobayashi S, Teramoto A
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 50 Issue: 5 Pages: 402-404

    • DOI

      10.2176/nmc.50.402

    • NAID

      10026469262

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiological study of the sandwich method in cervical anterior fusion using autologous vertebral bone grafts2010

    • Author(s)
      Kim K, Isu T, Sugawara A, Morimoto D, Matsumoto R, Isobe M, Mishina M, Kobayashi S, Teramoto A.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 17 Issue: 4 Pages: 450-4

    • DOI

      10.1016/j.jocn.2009.07.118

    • Related Report
      2011 Final Research Report
  • [Journal Article] Syringomyelia Associated with Chiari I Malformation Treated with Foramen Magnum Decompression and Duraplasty Using a Polyglycolic Acid Patch and Fibrin Glue: A Case Report2010

    • Author(s)
      Sugawara A, Isu T, Kim K, Matsumoto R, Isobe M, Ogasawara K.
    • Journal Title

      Journal of Nippon Medical School

      Volume: 77 Issue: 4 Pages: 221-225

    • DOI

      10.1272/jnms.77.221

    • NAID

      130004057372

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2011 Final Research Report
  • [Journal Article] Concomitant Cranial and Lumbar Subdural Hematomas.2010

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Neurologia Medico-Chirurgica

      Volume: 50 Pages: 402-404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological study of the sandwich method in cervical anterior fusion using autologous vertebral bone grafts.2010

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 17 Pages: 450-454

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological study of the sandwich method in cervical anterior fusion using autologous vertebral bone grafts.2010

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Journal of Clinical Neuroscience 17

      Pages: 450-454

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of cervical OPLL by cervical anterior fusion using autologous vertebral bone grafts2009

    • Author(s)
      Kim K, Isu T, Sugawara A, Morimoto D, Matsumoto R, Isobe M, Mishina M, Kobayashi S, Teramoto A.
    • Journal Title

      Acta Neurochirurgica

      Volume: 151 Issue: 11 Pages: 1549-55

    • DOI

      10.1007/s00701-009-0478-z

    • Related Report
      2011 Final Research Report
  • [Journal Article] Surgical Treatment of Spinal Lipoma Without Spina Bifida at Lumbar Region -Three Case Reports-2009

    • Author(s)
      Sugawara A, Kim K, Isobe M, Matsumoto R, Isu T.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 49 Issue: 12 Pages: 616-618

    • DOI

      10.2176/nmc.49.616

    • NAID

      10025949612

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
  • [Journal Article] Intracerebral Hemorrhage Caused by a Neoplastic Aneurysm From Pleomorphic Lung Carcinoma -Case Report-2009

    • Author(s)
      Nomura R, Yoshida D, Kim K, Kobayashi S, Teramoto A
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 49 Issue: 1 Pages: 33-36

    • DOI

      10.2176/nmc.49.33

    • NAID

      110007028642

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of cervical OPLL by cervical anterior fusion using autologous vertebral bone grafts.2009

    • Author(s)
      Kim Kyongsong
    • Journal Title

      Acta Neurochirurgica(Wien) 161

      Pages: 1549-1555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腰部脊柱管狭窄症の最新治療2009

    • Author(s)
      金景成
    • Journal Title

      脳と神経 61

      Pages: 655-662

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Incidental Detection of Thyroid Nodules at MRI of The Cervical Spine.

    • Author(s)
      Kim K, Emoto N, Mishina M, Okada S, Isu T, Yoshida D, Kobayashi S, Teramoto A.
    • Journal Title

      Neurologia Medico Chirurgica(Tokyo)

      Volume: (In press)

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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