Project/Area Number |
21791386
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
HAYATA Tadayoshi Tokyo Medical and Dental University, 難治疾患研究所, 助教 (40420252)
|
Research Collaborator |
江面 陽一 東京医科歯科大学, 難治疾患研究所, 助教 (50333456)
野田 政樹 東京医科歯科大学, 難治疾患研究所, 助教 (50231725)
西中村 隆一 熊本大学, 発生医学研究所, 教授 (70291309)
浅島 誠 東京大学, 大学院・総合文化研究科, 名誉教授 (00090564)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 骨芽細胞 / 骨形成 / BMP / TGF-β / SMAD1 / ユビキチン化 / 脱リン酸化酵素 |
Research Abstract |
Bone morphogenetic protein (BMP) plays crucial roles in skeletal formation, and its signal level is regulated properly by negative regulators. In the present study, I investigated involvement of novel BMP inhibitor Dullard in bone formation. I found that Dullard is localized in intracellular membrane structure, expressed in osteoblast, and suppress BMP signaling at least at intracellular signal transducer Smad1 level.
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