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Spinal plasticity of new chronic cervical cord compression model in rat.

Research Project

Project/Area Number 21791388
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionUniversity of Fukui

Principal Investigator

KUBOTA Masahumi  University of Fukui, 医学部附属病院, 理学療法士 (60422672)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords脊髄慢性圧迫 / 行動学的評価 / MR画像 / 前角細胞 / ラット / 脊髄 / 慢性圧迫 / 運動機能 / 可塑性 / トレッドミル / MRI / 脊髄横断面積 / SDNRs / BBBスケール
Research Abstract

In this study, we produced a new animal model of chronic cervical compression capable of reproducing the clinical course without laminectomy using rats. This model might reproduce characteristic features of clinical chronic cervical cord compression, including progressive motor and sensory disturbances after a latency and insidious neuronal loss; representing well the chronic compression of cervical spine cord in humans.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Development of Chronic Cervical Cord Compression Model in Rat : Changes of the Neurological Behaviors, Radiological and Pathological Findings.2011

    • Author(s)
      Kubota M, Kobayashi S, Nonoyama T, Shimada S, Takeno K, Miyazaki T, Guerrero AR, Iwamoto H, Baba H.
    • Journal Title

      J Neurotrauma. 28(3)

      Pages: 459-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Chronic Cervical Cord Compression Model in Rat : Changes of the Neurological Behaviors, Radiological and Pathological Findings.2011

    • Author(s)
      Kubota M, Kobayashi S, Nonoyama T, Shimada S, Takeno K, Miyazaki T, Guerrero AR, Iwamoto H, Baba H.
    • Journal Title

      J Neurotrauma.

      Volume: 28 Pages: 459-467

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット頚髄慢性圧迫モデルにおける最大トレッドミル速度を用いた客観的評価2010

    • Author(s)
      久保田雅史, 小林茂, 野々山忠芳, 竹野建一, 宮崎剛, 馬場久敏
    • Journal Title

      日本脊髄障害医学会誌 23(1)

      Pages: 51-52

    • Related Report
      2010 Final Research Report
  • [Journal Article] ラット頚髄慢性圧迫モデルにおける最大トレッドミル速度を用いた客観的評価2010

    • Author(s)
      久保田雅史, 小林茂, 野々山忠芳, 竹野建一, 宮崎剛, 馬場久敏
    • Journal Title

      日本脊髄障害医学会誌

      Volume: 23 Pages: 51-52

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ラット慢性頚椎脊柱管狭窄モデルにおける脊髄の変化:モデル作成一年後のMR像及び組織学的変化2009

    • Author(s)
      久保田雅史, 小林茂, 野々山忠芳, 竹野建一, 宮崎剛, 馬場久敏
    • Journal Title

      日本脊髄障害医学会誌 22(1)

      Pages: 138-139

    • Related Report
      2010 Final Research Report
  • [Presentation] Changes of locomotor function and pathology after chronic compression of the cervical cord in rats.2010

    • Author(s)
      Kubota M, Kobayashi S, Matsuo H, Miyazaki T, Takeno K, Shimada S, Sasaki S, Baba H.
    • Organizer
      7th Combined meeting of the orthopaedic research societies
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ラット慢性頚髄圧迫モデルにおける病理学的変化2010

    • Author(s)
      久保田雅史, 小林茂, 松尾英明, 竹野建一, 宮崎剛, 馬場久敏
    • Organizer
      第45回日本脊髄障害医学会
    • Place of Presentation
      松本
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Production of Chronic Cervical Spinal Cord Compression Model in Rat.Changes of the Neurological Behaviors, Radiological And Pathological Features with Aging.2010

    • Author(s)
      Kubota M, Kobayashi S, Matsuo H, Miyazaki T, Takeno K, Shimada S, Sasaki S, Alexander G, Baba H.
    • Organizer
      56th Annual Meeting of the Orthopaedic Research Society(ORS)
    • Place of Presentation
      New Orleans, Louisiana.
    • Year and Date
      2010-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット慢性頚椎脊柱管狭窄モデルにおけるトレッドミル最大歩行速度の検討2009

    • Author(s)
      久保田雅史, 小林茂, 佐々木伸一, 嶋田誠一郎, 松尾英明, 竹野建一, 宮崎剛, 馬場久敏
    • Organizer
      第44回日本脊髄障害医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット頸髄慢性圧迫モデルの解析:行動学的評価, MR像, 病理学的検討2009

    • Author(s)
      久保田雅史, 小林茂, 佐々木伸一, 嶋田誠一郎, 松尾英明, 竹野建一, 宮崎剛, 岩本久雄, 馬場久敏
    • Organizer
      第24回日本整形学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット頸髄慢性圧迫モデルの解析:行動学的評価,MR像,病理学的検討2009

    • Author(s)
      久保田雅史, 小林茂, 佐々木伸一, 嶋田誠一郎, 松尾英明, 竹野建一, 宮崎剛, 岩本久雄, 馬場久敏
    • Organizer
      第24回日本整形学会基礎学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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