The role of SIRT1 in chondrocytes

• Project/Area Number: 21791393
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: MATSUSHITA Takehiko Kobe University, 医学部附属病院, 特命助教 (40467650)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 関節病学 / SIRT1 / 軟骨 / 変形性関節症 / SIET1 / 軟骨細胞

Research Abstract

In this study, we found that the overexpression of SRIT1 counteracted against the IL-1β- induced expression of cartilage degrading enzymes, which presumably play important roles in cartilage degradation. Our study suggested that SIRT1 can play protective roles in chondrocytes.

Research Products

• [Journal Article] Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. (2011)
  • Author(s): Fujita N, et al.
  • Journal Title: Journal of Orthopaedic Research Volume: 29 Pages: 511-5
  • Peer Reviewed
• [Journal Article] Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. (2010)
  • Author(s): Fujita N, Matsushita T, et al.
  • Journal Title: Journal of Orthopaedic Research 29 Pages: 511-5
  • Peer Reviewed
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes. (2011)
  • Author(s): Sasaki H, Matsushita T, et al.
  • Organizer: 57th annual Meeting of the Orthopaedic Research Societies.
  • Place of Presentation: Long Beach, USA
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes (2011)
  • Author(s): Sasaki H, et al
  • Organizer: 57th annual Meeting of the Orthopaedic Research Societies
  • Place of Presentation: Long Beach, (USA)
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes. (2010)
  • Author(s): Sasaki H, Matsushita T, et al.
  • Organizer: International Cartilage Repair Society.
  • Place of Presentation: Barcelona, Spain
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes. (2010)
  • Author(s): Sasaki H, Matsushita T, et al.
  • Organizer: 7th Combined Meeting of the Orthopaedic Research Societies.
  • Place of Presentation: Kyoto
• [Presentation] SIRT1の過剰発現はヒト軟骨細胞においてIL-1β誘導による変形性関節症性様の遺伝子発現変化を抑制する. (2010)
  • Author(s): 佐々木宏, 松下雄彦, 他
  • Organizer: 日本整形外科基礎学術集会
  • Place of Presentation: 京都
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes (2010)
  • Author(s): Sasaki H, et al.
  • Organizer: International Cartilage Repair Society
  • Place of Presentation: Barcelona, (Spain)
• [Presentation] Overexpression of SIRT1 inhibits osteoarthritic gene expression changes induced by interleukin-1ss in human chondrocytes (2010)
  • Author(s): Sasaki H, et al.
  • Organizer: 7th Combined Meeting of the Orthopaedic Research Societies
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] SIRT1の過剰発現はヒト軟骨細胞においてIL-1β誘導による変形性関節症性様の遺伝子発現変化を抑制する (2010)
  • Author(s): 佐々木宏, 他
  • Organizer: 日本整形外科基礎学術集会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Remarks] ホームページ等