Functional analysis of membrane proteins whose expression were controlled by NFAT2/NFATc1 in mature osteoclasts
| Project/Area Number |
21791394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KITAGAWA Norihiro Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (30294284)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 破骨細胞 / 骨吸収 / NFATc1 / ITAM / 骨代謝 / NFAT2 / 膜タンパク質 / アクチン / HB-EGF / シグナルシーケンストラップ / ectodomain shedding |
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| Research Abstract |
Since NFATc1/NFAT2 is essential for inducing the entire processes of multinucleated cell formation, it seems to be reasonable to speculate that NFATc1 may regulate the expression of membrane proteins which control cell fusion and bone resorption. In this research, we found that 1) HB-EGF suppress osteoblast differentiation through the induction of Twist2 and suppression of nuclear translocation of Smad1, and 2) RADIO acts as a DAP12-associated receptor and is essential for the formation of functional osteoclasts through the regulation of actin-ring formation.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] The 1-Ser analog #290 promotes bone recovery in OP and RA mice.2011
Author(s)
Bahtiar, A., Nakamura, T., Kishida, K., Katsura, J., Nitta, M., Ishida-Kitagawa, N., Ogawa, T., Takeya, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Purification and identification of lactoperoxidase in milk basic proteins as an inhibitor of osteoclastogenesis.2011
Author(s)
Morita, Y, Ono, A., Serizawa, A., Yogo, K., Ishida-Kitagawa, N., Takeya, T., Ogawa T.
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Journal Title
J.Dairy Sci. 94
Pages: 2270-9
Related Report
Peer Reviewed
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[Journal Article] Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling.2011
Author(s)
Bao, X., Ogawa, T., Se, S., Akiyama, M., Bahtiar, A., Takeya, T., Ishida-Kitagawa, N.竹家達夫, 北川(石田)教弘
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Journal Title
Biochem.Biophys.Res.Commun. 405
Pages: 533-7
Related Report
Peer Reviewed
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[Journal Article] Identification and fUnctional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.2011
Author(s)
Sato, M., Maruoka, M., Yokota, N., Kuwano, M., Matsui, A., Inada, M., Ogawa, T., Ishida-Kitagawa, N., Takeya, T.小川拓哉, 北川(石田)教弘, 竹家達夫
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Journal Title
FEBS Lett. 585
Pages: 834-40
Related Report
Peer Reviewed
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[Journal Article] Potential involvement of Twist2 and Erk in the regulation of osteoblastogenesis by HB-EGF-EGFR signaling.2010
Author(s)
Nakamura, T., Toita, H., Yoshimoto, A., Nishimura, D., Takagi, T., Ogawa, T., Takeya, T., Ishida-Kitagawa, N.
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Journal Title
Cell Struct.Funct. 35
Pages: 53-61
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo.2009
Author(s)
Bahtiar, A., Matsumoto, T., Nakamura, T., Akiyama, M., Yogo, K., Ishida-Kitagawa, N., Ogawa, T., Takeya, T.北川(石田)教弘, 小川拓哉, 竹家達夫
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Journal Title
J.Biol.Chem. 284
Pages: 34157-66
Related Report
Peer Reviewed
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