The function of glia limitans in spinal cord injury

• Project/Area Number: 21791398
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: YONEZAWA Tomoko Okayama University, 大学院・医歯薬学総合研究科, 助教 (30304299)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 脊椎脊髄病学 / 脊髄損傷 / アストログリア

Research Abstract

Astroglia form a glia limitans around the injured tissue after spinal cord injury. We used a mouse spinal cord injury model and found that the glia limitans was associated with the suppression of infiltration of inflammatory cells and the perivascular space provides a conduit for inflammatory cells to the expansion from the injury core. In addition, we found that type IV collagen induced expression of thrombospondin-1 in astrocytes. Our results suggest that glia limitans play an important role in the repair process following injured central nervous tissue.

Research Products

• [Journal Article] Separation of the Perivascular Basement Membrane Provides a Conduit for Inflammatory Cells in a Mouse Spinal Cord Injury Model. (2010)
  • Author(s): Tomoyuki Takigawa, Tomoko Yonezawa, Teruhito Yoshitaka, Jun Minaguchi, Masae Kurosaki, Masato Tanaka, Yoshikazu Sado, Aiji Ohtsuka, Toshifumi Ozaki, Yoshifumi Ninomiya.
  • Journal Title: Journal of Neurotrauma 27(4) Pages: 739-751
  • Peer Reviewed
• [Journal Article] Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin a1b1 in astrocytes. (2010)
  • Author(s): Tomoko Yonezawa, Shunji Hattori, Junko Inagaki, Masae Kurosaki, Tomoyuki Takigawa, Satoshi Hirohata, Toru Miyoshi, Yoshifumi Ninomiya.
  • Journal Title: GLIA 58(7)(cover illustration採用) Pages: 755-767
  • Peer Reviewed
• [Journal Article] Separation of the Perivascular Basement Membrane Provides a Conduit for Inflammatory Cells in a Mouse Spinal Cord Injury Model (2010)
  • Author(s): Tomoyuki Takigawa
  • Journal Title: Journal of Neurotrauma Volume: 27 Pages: 739-751
  • Peer Reviewed
• [Journal Article] Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin α1β1 in astrocytes (2010)
  • Author(s): Tomoko Yonezawa
  • Journal Title: GLIA 58 Pages: 755767-755767
  • Peer Reviewed
• [Journal Article] The 3'-untranslated region of ADAMTS 1 regulates its mRNA stability. (2009)
  • Author(s): Omer Fark Hatipoglu, Satoshi Hirohata, Kursat Oguz Yaykasli, Mehmet Zeynel Cilek, Kadir Demircan, Ryoko Shinohata, Tomoko Yonezawa, Toshitaka Oohashi, Shizo Kusachi, Yoshifumi Ninomiya.
  • Journal Title: Acta Med Okayama 63(2) Pages: 79-85
  • Peer Reviewed
• [Presentation] アストロサイトのサイトカイン産生に対するIV型コラーゲンの作用 (2011)
  • Author(s): 米澤朋子
  • Organizer: 第43回日本結合組織学会学術大会・第58回マトリックス研究会大会合同学術集会
  • Place of Presentation: 大分(発表確定)
  • Year and Date: 2011-06-10
• [Presentation] 中枢神経組織の創傷治癒過程における細胞外マトリックスとアストロサイト (2009)
  • Author(s): 米澤朋子, 二宮善文
  • Organizer: 第147回日本獣医学会学術集会
  • Place of Presentation: 栃木県総合文化センター
• [Remarks] ホームページ
  • URL: http://mbb2.med.okayama-u.ac.jp/