Spinal cord regeneration promoted by the construction of neurovascular niche
| Project/Area Number |
21791399
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMEI Naosuke Hiroshima University, 病院, 病院助教 (70444685)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 移植 / 再生医療 / 再生医学 / 神経科学 / 移植・再生医療 |
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| Research Abstract |
The transplantation of Jagged1+/+ endothelial progenitor cells but not Jagged1-/- endothelial progenitor cells increased the number of reactive astrocytes during acute phase and improved functional recovery following spinal cord injury. Expression of the Notch effector Hes5 was upregulated in the injured spinal cord after Jagged1+/+ endothelial progenitor cell transplantation. In addition, Jagged1+/+ endothelial progenitor cells exhibited not only great pro-angiogenic effect but also morphologically abnormal vessel stabilization compared with Jagged1-/- endothelial progenitor cells in injured spinal cord. Thus, endothelial progenitor cells promoted the repair of injured spinal cord through the induction of Notch-dependent gliogenesis and vascular regulation.
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Report
(3 results)
Research Products
(39 results)
