| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The transplantation of Jagged1+/+ endothelial progenitor cells but not Jagged1-/- endothelial progenitor cells increased the number of reactive astrocytes during acute phase and improved functional recovery following spinal cord injury. Expression of the Notch effector Hes5 was upregulated in the injured spinal cord after Jagged1+/+ endothelial progenitor cell transplantation. In addition, Jagged1+/+ endothelial progenitor cells exhibited not only great pro-angiogenic effect but also morphologically abnormal vessel stabilization compared with Jagged1-/- endothelial progenitor cells in injured spinal cord. Thus, endothelial progenitor cells promoted the repair of injured spinal cord through the induction of Notch-dependent gliogenesis and vascular regulation.
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