• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathophysiology of steroid-induced osteonecorsis

Research Project

Project/Area Number 21791402
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

MOTOMURA Goro  九州大学, 大学病院, 助教 (50529857)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords骨壊死 / 骨壊死修復 / 大腿骨頭壊死症 / ステロイド性骨壞死
Research Abstract

We assessed which part of the femoral head was the key point of a collapse, and also examined whether a collapsed region was associated with the size of necrotic lesion. Then, the results suggested that a collapse may begin at the lateral boundary of the necrotic lesion, and the size of the necrotic lesion seemed to contribute to the distribution of a collapse. We also examined the reparative process of osteonecrosis using SPECT/CT with 99mTc methylene diphosphonate. Then, during the time before collapse, there was a gradual increase in the tracer uptake around the necrotic lesion, shifting the main region from anteriorly to laterally.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (21 results)

  • [Journal Article] Midterm results of transtrochanteric anterior rotational osteotomy combined with shelf acetabuloplastv for osteonecrosis with acetabular2012

    • Author(s)
      Motomura G., et al.
    • Journal Title

      J Orthop Sci

      Volume: 17 Issue: 3 Pages: 239-243

    • DOI

      10.1007/s00776-012-0205-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subclinical infection associated with delayed union after transtrochanteric rotational osteotomy2012

    • Author(s)
      Motomura G, Yamamoto T, Inoue S, Nakashima Y, Mawatari T, Iwamoto Y
    • Journal Title

      Orthopedic Research and Reviews

      Volume: 4 Pages: 5-8

    • URL

      http://dx.doi.org/10.2147/ORR.S28896

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特発性大腿骨頭壊死症における圧潰部位の形態学的検討2012

    • Author(s)
      本村悟朗
    • Journal Title

      整形外科

      Volume: 63 Pages: 1201-1203

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 【運動器疾患の画像診断】 その他の画像診断2012

    • Author(s)
      本村悟朗、山本卓明、岩本幸英
    • Journal Title

      骨SPECT/CT 融合画像を用いた大腿骨頭壊死症の病態評価 別冊整形外科

      Volume: 62 Pages: 208-210

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subclinical infection associated with delayed union after tranctrochanteric rotational osteotomy2012

    • Author(s)
      Motomura G
    • Journal Title

      Orthopedic Research and Reviews

      Volume: 4 Pages: 5-8

    • DOI

      10.2147/orr.s28896

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hip Joint2012

    • Author(s)
      本村悟朗
    • Journal Title

      特発性大腿骨頭壊死症に対するbipolar型人工骨頭置換術の成績不良因子の検証

      Volume: 31 Pages: 17-19

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 骨SPECT/CT融合画像を用いた大腿骨頭壊死症の病態評価2012

    • Author(s)
      本村悟朗
    • Journal Title

      別冊整形外科

      Volume: 62 Pages: 208-210

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Morphological analysis of collapsed regions in osteonecrosis of the femoral head2011

    • Author(s)
      Motomura G, Yamamoto T, Yamaguchi R, Ikemura S, Nakashima Y, Mawatari T, Iwamoto Y
    • Journal Title

      J Bone Joint Surg Br

      Volume: 93 Issue: 2 Pages: 184-7

    • DOI

      10.1302/0301-620x.93b225476

    • NAID

      40019444479

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大腿骨頭の骨化障害が示唆された2例2011

    • Author(s)
      小早川和、本村悟朗, ら
    • Journal Title

      整形外科

      Volume: 62 Pages: 450-454

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological Analysis of Collapsed Regions in Osteonecrosis of the Femoral Head2011

    • Author(s)
      Motomura G, et al
    • Journal Title

      Journal of Bone and Joint Surgery, Br

      Volume: 93(2) Pages: 184-187

    • NAID

      40019444479

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term Outcome of Transtrochanteric Anterior Rotational Osteotomy for Osteonecrosis of the Femoral Head in Patients with Systemic Lupus Erythematosus2010

    • Author(s)
      Motomura G, Yamamoto T, Suenaga K, Nakashima Y, Mawatari T, Ikemura S, Iwamoto Y
    • Journal Title

      Lupus 2010

      Volume: 19 Issue: 7 Pages: 860-5

    • DOI

      10.1177/0961203310361896

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head in patients with systemic lupus eryt-hematosus2010

    • Author(s)
      Motomura G, et al
    • Journal Title

      Lupus

      Volume: 19(7) Pages: 860-865

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midterm results of transtrochanteric anterior rotational osteotomy combined with shelf acetabuloplasty for osteonecrosis with acetabular dysplasia : a preliminary report

    • Author(s)
      Motomura G, et al
    • Journal Title

      Journal of Orthopaedic Science

      Volume: (掲載決定)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of transtrochanteric anterior rotational osteotomy for osteoncrosis of the femoral head in patients with systemic lupus eryt-hematosus

    • Author(s)
      Motomura G, et al
    • Journal Title

      Lupus (掲載決定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bone SPECT/CT imaging in osteonecrosis of the femoral head2013

    • Author(s)
      Motomura G, et al
    • Organizer
      The 17th International Symposium on Bone Circulation ARCO
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2013-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone SPECT/CT Imaging in Osteonecrosis of the Femoral Head2013

    • Author(s)
      Motomura G
    • Organizer
      The 17th International Symposium on Bone Circulation ARCO 2013
    • Place of Presentation
      Chicago
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphological analysis of collapsed regions in osteonecrosis of the femoral head2012

    • Author(s)
      Motomura G, et al
    • Organizer
      The 16th International Symposium on Bone Circulation
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2012 Final Research Report
  • [Presentation] 臼蓋形成不全を伴う大腿骨頭壊死症に対する関節温存手術-臼蓋形成術併用大腿骨頭前方回転骨切り術の中期成績-2012

    • Author(s)
      本村悟朗ら
    • Organizer
      第85回日本整形外科学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 臼蓋形成不全を伴う大腿骨頭壊死症に対する関節温存手術2012

    • Author(s)
      本村悟朗
    • Organizer
      第85回日本整形外科学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大腿骨頭壊死症の骨SPECT/CT融合画像2012

    • Author(s)
      本村悟朗
    • Organizer
      第39回日本股関節学会
    • Place of Presentation
      新潟
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphological analysis of collapsed regions in osteonecrosis of the femoral head2012

    • Author(s)
      Motomura G
    • Organizer
      The 16^<th> international symposium on Bone Circulation
    • Place of Presentation
      Brussels, Begium
    • Related Report
      2011 Annual Research Report
  • [Presentation] Morphological analysis of collapsed regions in osteonecrosis of the femoral head2011

    • Author(s)
      Motomura G, et al
    • Organizer
      2011 Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Long Beach, Calfornia, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 特発性大腿骨頭壊死症に対する圧潰の起点と部位2011

    • Author(s)
      本村悟朗ら
    • Organizer
      第84回日本整形外科学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 臼蓋形成術を併用した大腿骨頭前方回転骨切り術の中期成績2011

    • Author(s)
      本村悟朗, ら
    • Organizer
      第38回日本股関節学会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特発性大腿骨頭壊死症に対するBipolar型人工骨頭置換術の成績不良因子の検証2011

    • Author(s)
      本村悟朗, ら
    • Organizer
      第38回日本股関節学会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] Morphological Analysis of Collapsed Regions in Osteonecrosis of the Femoral Head2011

    • Author(s)
      Motomura G, et al
    • Organizer
      Annual meeting of the Orthopaedic Research Society
    • Place of Presentation
      Long Beach, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腿骨頭前方回転骨切り術の長期結果~SLE症例における検討~2010

    • Author(s)
      本村悟朗ら
    • Organizer
      第83回日本整形外科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] SLE症例における大腿骨頭壊死症の治療~大腿骨頭前方回転骨切り術の長期結果~2010

    • Author(s)
      本村悟朗ら
    • Organizer
      第54回日本リウマチ学会総会・学術総会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] ステロイド投与量が骨壊死の発生・修復に及ぼす影響2010

    • Author(s)
      本村悟朗, ら
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 特発性大腿骨頭壊死症における圧潰の起点と部位2010

    • Author(s)
      本村悟朗, ら
    • Organizer
      日本股関節学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大腿骨頭前方回転骨切り術の長期結果~SLE症例における検討~2010

    • Author(s)
      本村悟朗, ら
    • Organizer
      日本整形外科学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long-term outcome of transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head in patients with systemic lupus erythematosus2009

    • Author(s)
      Motomura G, et al
    • Organizer
      The 15thInternational Symposium on Bone Circuration ARCO
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Long-term outcome of transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head in patiets with systemic lupus eryt-hematosus2009

    • Author(s)
      Motomura G, et al
    • Organizer
      The 15^<th> International Symposium on Bone Circul-ation
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] SLE症例における大腿骨頭前方回転骨切り術の長期結果2009

    • Author(s)
      本村悟朗, ら
    • Organizer
      第36回日本股関節学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特発性大腿骨頭壊死症に対するバイポーラ型人工骨頭置換術の中期成績および健康関連Quality of Life2009

    • Author(s)
      本村悟朗, ら
    • Organizer
      第82回日本整形外科学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi