Homing of osteogenic progenitors to site of new bone formation in artificial bone substitute
| Project/Area Number |
21791406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUMAGAI Ken Yokohama City University, 医学部, 助教 (10468176)
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| Research Collaborator |
MUSCHLER George F Orthopaedic Research Center, Cleveland Clinic, Director
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 人工骨 / 骨形成 / 末梢血由来細胞 / ホーミング / 骨前駆細胞 / 骨再生 |
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| Research Abstract |
This study demonstrated that bone formation was stimulated by the addition of bone marrow cells to subcutaneously implanted porous β-TCP blocks in mouse. The data also suggested that recipient derived osteogenic cells migrate into the ceramic pores and contribute to new bone formation. A possible source of osteogenic cells is cells adjacent to local site or circulating osteogenic cells.
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Report
(3 results)
Research Products
(12 results)
