The antitumor effect of histone deacetylase inhibitor against multidrug-resistant Ewing' s sarcoma cells

• Project/Area Number: 21791409
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kitasato University
• Principal Investigator: OKADA Takamitsu Kitasato University, 医学部, 講師 (70525550)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 多剤耐性因子 / ピストン脱アセチル化酵素阻害剤 / オートファジー / ユーイング肉腫 / アポトーシス抵抗性 / 多剤耐性 / ヒストン脱アセチル化酵素阻 / SAHA / Ewing肉腫 / autophagic cell death / programed cell death type 2

Research Abstract

We showed that histone deacetylase inhibitor SAHA induced apoptosis against parental drug-sensitive Ewing's sarcoma cells, however induced autophagic cell death against multidrug-resistant cells which was resistant to the apoptosic signals. Furthermore, we showed that SARA exhibited the antitumor effect against the animal model of multidrug-resistant Ewing's sarcoma.