Regulation of osteoclastogenesis by transcriptional repressors
| Project/Area Number |
21791410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 骨 / 軟骨代謝学 / 整形外科 / 破骨細胞 / 転写制御 |
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| Research Abstract |
Transcriptional regulation in osteoclast differentiation was reportedly involved in activating expression of genes which were responsible for osteoclast formation and functions. We found that two transcription repressors, Bcl6 and Blimp1, were essential for osteoclast differentiation. Our data evidenced that Bcl6 repressed osteoclastogenesis in undifferentiated osteoclast precursors, and Blimp1 promoted osteoclast differentiation through suppressing Bcl6 at the transcriptional level under stimulation by osteoclastogenic cytokine, RANKL. The Blimp1-Bcl6 axis is crucial to regulate osteoclastogenesis.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis2010
Author(s)
Yoshiteru Miyauchi, Ken Ninomiya, Hiroya Miyamoto, Akemi Sakamoto, Ryotaro Iwasaki, Hiroko Hoshi, Kana Miyamoto, Wu Hao, Shigeyuki Yoshida, Hideo Morioka, Kazuhiro Chiba, Shigeaki Kato, Takeshi Tokuhisa, Mitinori Saitou, Yoshiaki Toyama, Toshio Suda, Takeshi Miyamoto
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Journal Title
Journal of Experimental Medicine 207
Pages: 751-762
Related Report
Peer Reviewed
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