Expression and functional analysis of CD44 and ADAM17in bone and soft tissue tumors

Research Project

Project/Area Number	21791413
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Keio University
Principal Investigator	NAKAYAMA Robert t. 慶應義塾大学, 医学部, 助教 (00365298)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	癌 / シグナル伝達 / 遺伝子 / 蛋白質 / 骨軟部腫瘍 / 転移 / CD4 / ADAM17 / 肉腫 / 発現解析 / CD44 / APAM17
Research Abstract	Many types of epithelial cancer are known to show their invasive motility and metastatic potential through a process called Epithelial-Mesenchymal Transition(EMT), in which cancer cells lose their epithelial morphology and acquire mesenchymal characteristics. We analyzed the clinical samples to elucidate expression and functions of CD44and TNFαconverting enzyme(TACE/ADAM17), key molecules in EMT, in primary malignant bone and soft tissue tumors which originally arise in the mesenchymal tissue.

Report

(4 results)