Expression and functional analysis of CD44 and ADAM17in bone and soft tissue tumors
| Project/Area Number |
21791413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 癌 / シグナル伝達 / 遺伝子 / 蛋白質 / 骨軟部腫瘍 / 転移 / CD4 / ADAM17 / 肉腫 / 発現解析 / CD44 / APAM17 |
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| Research Abstract |
Many types of epithelial cancer are known to show their invasive motility and metastatic potential through a process called Epithelial-Mesenchymal Transition(EMT), in which cancer cells lose their epithelial morphology and acquire mesenchymal characteristics. We analyzed the clinical samples to elucidate expression and functions of CD44and TNFαconverting enzyme(TACE/ADAM17), key molecules in EMT, in primary malignant bone and soft tissue tumors which originally arise in the mesenchymal tissue.
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Report
(4 results)
Research Products
(3 results)
