Molecular analysis for oxidative stress-induced senescent motor weakness

• Project/Area Number: 21791415
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Juntendo University
• Principal Investigator: NOJIRI Hidetoshi Juntendo University, 医学部, 助教 (10317456)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 加齢 / 酸化ストレス / Mn-SOD / 骨格筋 / ミトコンドリア / ATP / 走行能力 / モデルマウス / SOD / 運動能力

Research Abstract

Oxidative stress in skeletal muscle causes severe disturbance of exercise activitywithout muscle atrophy

Research Products

• [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy. (2010)
  • Author(s): Kuwahara H, Horie T, Ishikawa S, Tsuda C, Kawakami S, Noda Y, Kaneko T, Tahara S, Tachibana T, Okabe M, Melki J, Takano R, Toda T, Morikawa D, Nojiri H, Kurosawa H, Shirasawa T, Shimizu T.
  • Journal Title: Free Radic Biol Med 48 Pages: 1252-1262
• [Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase gene. (2010)
  • Author(s): Takahiko Shimizu, Hidetoshi Nojiri, Satoru Kawakami, Satoshi Uchiyama, Takuji Shirasawa.
  • Journal Title: Geriatr Gerontol Int 10
  • NAID: 10027273145
• [Journal Article] Model mice for tissue-specific deletion of the manganese superoxide dismutase gene (2010)
  • Author(s): Shimizu T., et al.
  • Journal Title: Geriatr Gerontol Int Volume: 10(Suppl1)
  • Peer Reviewed
• [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy (2010)
  • Author(s): Kuwahara H., et al.
  • Journal Title: Free Rad.Biol.Med. Volume: 48 Pages: 1252-62
  • Peer Reviewed
• [Journal Article] Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy (2010)
  • Author(s): Kuwahara H., et al.
  • Journal Title: Free Rad.Biol.Med. (印刷中)
  • Peer Reviewed
• [Presentation] 筋細胞におけるミトコンドリア内酸化ストレスは呼吸鎖を障害し著しい運動能力の低下をきたす (2010)
  • Author(s): 野尻英俊, 桑原宏朋, 森川大智, 斎田良知, 金子和夫, 清水孝彦
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都