Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategies
| Project/Area Number |
21791419
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokai University |
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Principal Investigator |
HIYAMA Akihiko Tokai University, 医学部, 助教 (00514382)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Daisuke 東海大学, 外科学系整形外科, 講師 (10408007)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 脊椎脊髄病学 / GlcAT-I / intervertebral disc / TGF-β / BMP2 / NFAT / Intervertebral disc / TonEBP / カルシウムシグナル |
|---|
| Research Abstract |
The goal of this investigation was to study the expression and regulation of β1,3-Glucuronosyltransferase-I (GlcAT-I), a key enzyme regulating GAG synthesis in cells of the intervertebral disc. There was a robust expression of GlcAT-I in the nucleus pulposus in vivo. We demonstrate that calcium regulates expressionof GlcAT-I, a critical enzyme required for GAG synthesis through TonEBP/NFAT5 and Cn-NFAT signaling pathways.
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Report
(3 results)
Research Products
(4 results)
