Repair of articular cartilage with scaffold-free chondrocyte plates

• Project/Area Number: 21791420
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Tokai University
• Principal Investigator: NAGAI Toshihiro Tokai University, 医学部, 助教 (20514376)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 軟骨修復 / 組織工学軟骨 / 同種移植 / 組織工学的軟骨 / scaffold free / tissue enginggred carti / allograft / chondromodulin-I

Research Abstract

In osteochondral defects of the articular cartilage, favorable repair can be achieved by restoration of the superficial layer region alone using scaffold free chondrocyte plates. And this study confirmed that in the early stage of transplantation, a good restoration effect of articular cartilage is seen with reparative cells derived from marrow that acquire antiangiogenic properties.

Research Products

• [Journal Article] Noninvasive evaluation of tissue engineered cartilage with time resolved laser induced fluorescence spectroscopy (2010)
  • Author(s): T.Kustuna, M.Sato, M.Ishihara, K.Furukawa, T.Nagai, T.Ushida, S.Kikuchi, J.Mochida
  • Journal Title: Tissue Engineering Part C Methods 16(3) Pages: 365-373
  • Peer Reviewed
• [Journal Article] Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair (2010)
  • Author(s): T.Nagai, et al
  • Journal Title: Arthritia Research & Therapy Volume: 12
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of tissue engineered cartilage with time -resolved laser-induced fluorescence spectroscopy (2009)
  • Author(s): Kutsuna T, Nagai T, et al.
  • Journal Title: Tissue Engineering Part C
  • Peer Reviewed
• [Presentation] 血管新生阻害剤(Bevacizumab)静脈内投与による関節軟骨修復の検討 (2011)
  • Author(s): 長井敏洋、佐藤正人、沓名寿治、太田直司、海老原吾郎、持田讓治
  • Organizer: 第10回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] Repair of articular cartilage with anti-VEGF antibody bevacizumab (2011)
  • Author(s): T.Nagai, M.Sato, T.Kutsuna, S.Ito, M.Kokubo, J.Mochida
  • Organizer: 2011 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Long Beach, Califolnia
• [Presentation] 抗VEGFヒト化モノクローナル抗体(Bevacizumab)による軟骨修復効果 (2010)
  • Author(s): 長井敏洋、佐藤正人、沓名寿治、太田直司、海老原吾郎、小久保舞美、持田讓治
  • Organizer: 第25回日本整形外科基礎学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-14
• [Presentation] 治血管新生阻害効果による関節軟骨修復の検討 (2010)
  • Author(s): 長井敏洋、佐藤正人、古川克子、沓名寿治、海老原吾郎、太田直司、伊藤聡、小久保舞美、鵜養拓、牛田多加志、持田讓
  • Organizer: 第29回日本運動器移植・再生医学研究会
  • Place of Presentation: 京都
  • Year and Date: 2010-09-25
• [Presentation] 血管新生阻害効果による関節軟骨修復の検討 (2010)
  • Author(s): 長井敏洋
  • Organizer: 第29回日本運動器移植・再生医学研究会
  • Place of Presentation: 京都
  • Year and Date: 2010-09-25
• [Presentation] 抗VEGFヒト化モノクローナル抗体(Bevacizumab)による関節軟骨修復効果 (2010)
  • Author(s): 長井敏洋、佐藤正人、沓名寿治、海老原吾郎、太田直司、持田讓治
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] Intravenous administration of Bevacizumab may contribute to better repair of articular cartilage. (2010)
  • Author(s): T.Nagai, M.Sato, T.Kutsuna, G.Ebihara, J.Mochida
  • Organizer: 56^<th> Orthopaedic Research Society
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Intravenous administration of Bevacizumab may contribute to better repair of articular cartilage (2010)
  • Author(s): T.Nagai, et al.
  • Organizer: 56th Annual Meeting of the Orthopedic Research Society
  • Place of Presentation: New Orleans
• [Presentation] 抗VEGFヒト化モノクローナル抗体(Bevacizumab)による軟骨修復効果 (2009)
  • Author(s): 長井敏洋、沓名寿治、太田直司、海老原吾郎、持田讓治
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-11-06
• [Presentation] Repair of articular cartilage with scaffold-free chondrocyte plates. (2009)
  • Author(s): T.Nagai, M.Sato, Furukawa.S.K, Ushida.T, J.Mochida
  • Organizer: 8^<th> world congress of the international cartilage repair society
  • Place of Presentation: Miami, Florida
• [Presentation] Repair of articular cartilage with scaffold-free chondrocyte plates (2009)
  • Author(s): T.Nagai, et al.
  • Organizer: 8th world congress of the international cartilage repairo society
  • Place of Presentation: Miami
• [Book] Tissue Engineering (2010)
  • Author(s): K.Furukawa, T.Nagai, et al
  • Total Pages: 20
  • Publisher: Scaffold-free Cartilage Tissue by Mechanical Stress for Tissue Engineering
• [Book] Scaffold-free Cartilage Tissue by Mechanical Stress Loading for Tissue Engineering.
  • Author(s): K.Furukawa, M.Sato, T.Nagai, S.Ting, J.Mochida, T.Ushida
  • Publisher: In Tech Tissue Engineering