Research of adiponectin in the pathogenesis of rheumatoid arthritis

Research Project

Project/Area Number	21791421
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthopaedic surgery
Research Institution	Tokyo Women's Medical University
Principal Investigator	IWAMOTO Takuji Tokyo Women's Medical University, 医学部, 助教 (10348675)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	関節リウマチ / アディポネクチン / 脂質代謝 / 関節液
Research Abstract	Rheumatoid arthritis is an intractable disease that causes progressive joint destruction. The pathogenesis of rheumatoid arthritis is still unknown. We examined the concentrations of the adiponectin secreted by the adipose cell that is considered to be a beneficial cytokine in metabolic syndrome. Although there is no difference in the concentration of serum adiponectin between rheumatoid arthritis patients and osteoarthritis patients, the concentration of intraarticular synovial adiponectin was higher in rheumatoid arthritis patients than in osteoarthritis patients. The adiponectin was thought to play some role in joint inflammation of patients with rheumatoid arthritis.