Research of adiponectin in the pathogenesis of rheumatoid arthritis
| Project/Area Number |
21791421
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
IWAMOTO Takuji Tokyo Women's Medical University, 医学部, 助教 (10348675)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 関節リウマチ / アディポネクチン / 脂質代謝 / 関節液 |
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| Research Abstract |
Rheumatoid arthritis is an intractable disease that causes progressive joint destruction. The pathogenesis of rheumatoid arthritis is still unknown. We examined the concentrations of the adiponectin secreted by the adipose cell that is considered to be a beneficial cytokine in metabolic syndrome. Although there is no difference in the concentration of serum adiponectin between rheumatoid arthritis patients and osteoarthritis patients, the concentration of intraarticular synovial adiponectin was higher in rheumatoid arthritis patients than in osteoarthritis patients. The adiponectin was thought to play some role in joint inflammation of patients with rheumatoid arthritis.
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Report
(3 results)
Research Products
(2 results)
