| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The aim of this study was to investigate the mechanism of bone remodeling while focusing on the integrity of osteocyte network. Both an in vitro experimental system that could apply local mechanical damage to the cultured osteocytes and an animal model that could give a fatigue microcrack to a mouse tibia were developed. A large deformation of the culture substrate or bone matrix damaged the osteocyte network, and apoptotic cells were derived around the necrotic osteocytes. This apoptotic cell induction would be a key response for initiating bone remodeling, by which a damaged bone matrix could be repaired locally and appositional bone formation would be occurred to compensate the drop of bone strength.
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