Satisfactory emergence from general anesthesia and its mechanisms

• Project/Area Number: 21791429
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tohoku University
• Principal Investigator: OHTANI Norimasa 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (60338879)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 麻酔薬 / 覚醒状態 / デクスメデトミジン / 術後痛 / エスモロール / デクスメデトミジ / 覚醒状 / デクスメデトミ / 覚醒 / 術後鎮痛 / デクスメデトミン / プロポフォール

Research Abstract

When co-administered with sevoflurane and propofol, the increasing doses of dexmedetomidine did not prolong emergence time from general anesthesia. IT administration of esmolol produced antinociceptive effects of short duration in a postoperative pain rat model.

Research Products

• [Journal Article] Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements : A randomized control trial (2011)
  • Author(s): Ohtani N, Yasui Y, Watanabe D, Kitamura M, Shoji S, Masaki E
  • Journal Title: J Anesth Volume: 25 Pages: 872-878
  • NAID: 10030448853
  • Peer Reviewed
• [Journal Article] Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements : A randomized control trial (2011)
  • Author(s): Ohtani N., et.al
  • Journal Title: Journal of Anesthesia Volume: 25 Issue: 6 Pages: 872-878
  • DOI: 10.1007/s00540-011-1239-8
  • NAID: 10030448853
  • Peer Reviewed
• [Journal Article] Postoperative pain status after intraoperative administration of dexmedetomidine as a general anesthetic adjuvant (2009)
  • Author(s): Yasuda M, Tachibana Y, Aoi A, Kurihara J, Ohtani N, Masaki E
  • Journal Title: Tohoku Univ Dent J Volume: 28 Pages: 43-48
  • NAID: 120002338957
  • Peer Reviewed
• [Presentation] Efficacy of intrathecal esmolol on heat-evoked responses in postoperative pain model (2010)
  • Author(s): Ohtani N, Tachibana Y, Aoi A, Yasui Y, Masaki E
  • Organizer: The 2010 annual meeting of American society of Anesthesiologist
  • Place of Presentation: San Diego, California
  • Year and Date: 2010-10-15
• [Presentation] Efficacy of intrathecal esmolol on heat-evoked responses in postoperative pain model. (2010)
  • Author(s): Ohtani N, et al.
  • Organizer: The 2010 annual meeting of American society of Anesthesiologist
  • Place of Presentation: San Diego, California USA
  • Year and Date: 2010-10-15
• [Presentation] The lateralized pain processing in the central amygdale of the rat model of neuropathic pain (2010)
  • Author(s): Yasui Y, Ikeda, Takahashi Y, Masaki E, Shoji K, Ohtani N, Kitamura S, Kato F
  • Organizer: 3rd International Congress on Neuropathic Pain
  • Place of Presentation: Greece, Athens
  • Year and Date: 2010-05-28