The neuroprotective effects of a combination of post-ischemic dexmedetomidine and hypothermia after transient forebrain ischemia in rats
| Project/Area Number |
21791430
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Akita University |
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Principal Investigator |
SATO Koji Akita University, 医学部, 助教 (80333938)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 一過性前脳虚血 / デクスメデトミジン / 虚血後投与 / 低体温 / 短期予後 / 長期予後 |
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| Research Abstract |
The combination of post-ischemic dexmedetomidine and hypothermia provided comparable short-term neuroprotection with either of the two therapies alone after transient forebrain ischemia in rats. The combination of pre-ischemic dexmedetomidine and hypothermia improved long-term histological outcome of hippocampal CA1 neurons compared with either of two therapies alone.
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Report
(3 results)
Research Products
(6 results)
