Molecular mechanisms for the development of morphine tolerance in neuropathic pain
Project/Area Number |
21791436
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Chiba University |
Principal Investigator |
DOBASHI Tamae Chiba University, 医学部附属病院, 助教 (10375694)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ストレス / 蛋白 / 脳・神経 / 小胞体ストレス / 神経因性疼痛 |
Research Abstract |
Morphine is a potent analgesic, but the molecular mechanism for tolerance formation for neuropathic pain is not fully understood. Recent studies have suggested that chronic endoplasmic reticulum (ER) stress might modulate intracellular signaling pathways, resulting in several chronic disorders, such as type II diabetes and interstitial pneumonia. We found that a chemical chaperone which improves ER protein folding capacity has a tendency to attenuate the development of morphine tolerance in wild-type mice with neuropathic pain, suggesting a possible clinical application of chemical chaperones in preventing morphine tolerance.
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Report
(3 results)
Research Products
(14 results)