| Project/Area Number |
21791438
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
HONDA Hiroyuki Niigata University, 医歯学総合病院, 特任助教 (20535174)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 周術期管理 / 脊髄虚血 / オピオイド / パッチクランプ / μ受容体 / ホールセル・パッチクランプ法 / 興奮性神経細胞死 |
|---|
| Research Abstract |
There is a possibility that perioperative administered opioids worsen paralysis caused by spinal cord ischemia. To elucidate the effects of opioids in spinal motoneurons and its significance during an ischemic insult, we conducted the electrophysiological experiments. We revealed that the opioids modulated synaptic transmission in spinal motoneurons, however, it did not exacerbate the ischemic injury. Our findings indicate that opioids administration during spinal cord ischemia should be considered as a potential component of anesthetics during aortic surgery.
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