The analgesic effects of neurosteroids at the level of spinal cord

• Project/Area Number: 21791439
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Niigata University
• Principal Investigator: IKOMA Miho 新潟大学, 医歯学総合病院, 講師 (30432082)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 疼痛管理学 / 脊髄 / 疼痛

Research Abstract

We investigated the effects of neurosteroids, DHEA and DHEAS on excitatory synaptic transmission in the dorsal horn neurons of the adult rat spinal cord using electrophysiological technique. We found that neurosteroids, DHEA and DHEAS also increased the release of the excitatory transmitter. These data indicate that DHEA and DHEAS modulate the excitability of dorsal horn neurons.

Research Products

• [Journal Article] オピオイドによる鎮痛作用 (2012)
  • Author(s): 生駒美穂, 河野達郎
  • Journal Title: Clinical neuroscience Volume: Vol.30 Pages: 152-154
• [Journal Article] Bupivacaine inhibits glutamatergic transmission in spinal dorsal horn neurons (2010)
  • Author(s): Furutani K, Ikoma M, Ishii H, BabaH, Kohno T
  • Journal Title: Anesthesiology Volume: 112 Pages: 138-143
  • NAID: 40016971459
  • Peer Reviewed
• [Presentation] 末梢および脊髄におけるオピオイド鎮痛(シンポジウム) (2011)
  • Author(s): 生駒美穂
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-19
• [Presentation] 末梢および脊髄におけるオピオイド鎮痛 (2011)
  • Author(s): 生駒美穂
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸(シンポジウム)(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] Action of neurosteroids, dehydroepiandrosteron sulfate(DHEAS) and dehydroepiandrosterone(DHEA), on the substantia gelatinosa neurons of the adult rat spinal cord (2010)
  • Author(s): Miho Ikoma
  • Organizer: 世界疼痛学会
  • Place of Presentation: モントリオール(カナダ)
• [Presentation] Action of neurosteroids, dehydroepiandrosteron sulfate (DHEAS) and dehydroepiandrosterone (DHEA), on the substantia gelatinosa neurons of the adult rat spinal cord (2010)
  • Author(s): Miho Ikoma
  • Organizer: 世界疼痛学会
  • Place of Presentation: モントリオール(カナダ)