Local anesthetics inhibit glutamatergic transmission in spinal dorsal horn neurons
| Project/Area Number |
21791440
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Niigata University |
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Principal Investigator |
FURUTANI Kenta Niigata University, 医歯学総合病院, 医員 (40535176)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 局所麻酔薬 / グルタミン酸受容体 / パッチクランプ / 痛み |
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| Research Abstract |
It is well established that local anesthetics block impulses in peripheral nerves through the inhibition of voltage-gated sodium channels. The glutamate receptors play an important role in the central nervous system, mediating rapid excitatory neurotransmission. In this study, we showed that local anesthetics inhibited the NMDA-type glutamate receptors in spinal dorsal horn neurons. These findings raise the possibility that the antinociceptive effect of bupivacaine may be due to direct modulation of NMDA receptors in superficial dorsal horn. In addition to voltage-gated sodium channels, the NMDA-type glutamate receptors are also important for anesthesia and analgesia induced by local anesthetics.
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Report
(3 results)
Research Products
(5 results)
