| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
It was revealed using whole-cell patch-clamp technique that a selectiveα2-adrenoceptor agonist contributed to its antinociceptive action throughα2A-andα2C-adrenoceptors in the spinal cord. In behavioral experiments, fentanyl was injected 4 times at 15-min intervals. Subsequently, morphine was injected at the end of the fentanyl effects. Withdrawal latencies did not decrease below baseline values in the hot plate test. Withdrawal latencies also remained steadily elevated during continuous high-dose remifentanil administration. These findings suggest that acute high-dose opioid treatment might prevent the development of opioid tolerance.
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