Identification of intracellular factors involved in the prevention of arrhythmias induced by volatile anesthetics.
| Project/Area Number |
21791447
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Osaka University |
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Principal Investigator |
IWASAKI Mitsuo Osaka University, 医学部附属病院, 医員 (80528365)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Yukio 大阪大学, 医学系研究科, 准教授 (60294063)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 不整脈 / 揮発性麻酔薬 / タンパク質 / リン酸化 / phosphatidylinositol 3-kinase / Akt / 内因性NO / 百日咳毒素感受性G蛋白質 / phosphatidylinositol 3-kinas / エピネフリン |
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| Research Abstract |
Activation of pertussis toxin-sensitive G protein, phosphatidylinositol 3-kinase-Akt-GSK3・signaling pathway and endogenous nitric oxide may be involved in prevention of adrenaline-induced arrhythmias during halothane anesthesia.
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Report
(3 results)
Research Products
(5 results)
