| Project/Area Number |
21791453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Research Collaborator |
HOJO Minoru 長崎大学, 病院, 助教 (00380957)
UEZONO Yasuhito 国立がん研究センター, 研究所, 部長 (20213340)
ANDO Yuko 長崎大学, 病院, 助教 (70580322)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | レミフェンタニル / 急性耐性 / オピオイド / リサイクル機構 / 二量体化受容体 / 共焦点レーザ顕微鏡 / 二量体 / FRET / ケタミン / 疼痛 |
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| Research Abstract |
Remifentanil might develop acute tolerance when infused at large dose. We investigated the effects of small-and large-doses of remifentanil on the internalization and recycling profiles of bothμ-opioid receptors(μOR) and dimerizedμ-δOR. There was no significant difference among the rate of internalizedμOR by remifentanil at any concentrations, whereas the percentages of internalizedμ-δOR by remifentanil increased in a concentration-dependent manner. The rate of recycling ofμOR and dimerizedμ-δOR was decreased when stimulated by remifentanil at large doses.μ-δOR internalized by remifentanil were recycled more thanμOR internalized at the same concentrations. These findings may account for the acute tolerance induced by large-doses of remifentanil.
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