Transcellular mechanisms of non-depolarizing muscle relaxant uptake

• Project/Area Number: 21791460
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Fukushima Medical University
• Principal Investigator: TAKAHASHI Shinichiro Fukushima Medical University, 医学部, 助教 (50457769)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ゲノム / 薬剤反応性 / 非脱分極性筋弛緩薬 / 剤反応性 / トランスポーター / 遺伝子多型 / ベクロニウム

Research Abstract

Research about the hepatocellular uptake mechanism of non-depolarizing muscle relaxants including vecuronium and rocuronium was performed. HepG2 cells which express Organic Cation Transporter 1 were used to examine if MPP uptake was inhibited by vecuronium and rocuronium. The results suggested that OCT1 was involved in hepatocellular uptake mechanisms of vecuronium and rocuronium. Further research is needed to test if polymorphism affect the uptake system.