| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
I and my colleagues revealed that expression of the active form variant of the Sema3A receptor(plexinA1) in the dorsal root ganglion could prevent neuropathic pain behavior in SNL model rat as same as intrathecal administration of recombinant Sema3A protein, and the expression pattern of down stream molecules of the Sema3A signaling was confirmed to be different in spinal cord dorsal horn and a dorsal root ganglion of the neuropathic pain model rat.
In paclitaxel-induced pain model rats, we revealed that(NGF) content was increased to about 1.4-fold in the dorsal horn of the spinal cord and the expression of the TrkA, which is one of the NGF receptor was increased about three-fold in dorsal root ganglia as compared to control rats.
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