| Project/Area Number |
21791465
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
UENO Hiroshi 京都府立医科大学, 医学研究科, 助教 (20381965)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 一側肺換気 / 急性肺損傷 / ARDS / 虚脱肺 / 炎症性メディエータ / 人工呼吸関連肺損傷 / 炎症性メディエーター / 低酸素性肺血管収縮 |
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| Research Abstract |
The aim of this study was to investigate the effect of one-lung ventilation(OLV) on acute lung injury(ALI), especially in relation to re-inflated after deflated lung. This experiment involved general anesthetized rats. OLV was performed for 60min, and then double-lung ventilation(DLV) was performed 60min(OLV group). Only DLV was performed for 120min(control group). No destructive change was observed in the control group. On the contrary, destruction of pulmonary cell walls, migration of inflammatory cells, and pulmonary hemorrhages were present in OLV group. In OLV group, such damaged change in deflated lung was more remarkable than in ventilated lung. Inflammatory cytokine(TNF-α、IL-1β、IL-6、IL-8), HMGB1 concentrations in both plasma and bronchoalveolar lavage fluid(BALF) in OLV group tended to be higher than in control group. Particularly in OLV group, HMGB1 concentration in BALF in deflated lung was higher than in ventilated lung. In conclusion, ALI following the OLV had possibility to caused by effect of deflated lung as well as injury of ventilated lung.
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