The regulatory mechanism of microvessels and calcium signaling through astrocyte.

• Project/Area Number: 21791471
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: NAKAHATA Katsutoshi 和歌山県立医科大学, 医学部, 助教 (70332971)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 星状細胞 / 振動性細胞内カルシウム濃度変化 / 麻酔薬 / 脳血管 / 血管平滑筋

Research Abstract

The cerebral microcirculation has a central role in supporting the neurological activity, yet our understanding how anesthesia affect the regulation mechanisms of local cerebral blood flow is extremely limited. We investigated the role of astrocyte in neurovascular coupling.

Research Products

• [Journal Article] Roles of neuronal nitric oxide synthase, oxidative stress and propofol in N-methyl-D-aspartate-induced dilation of cerebral arterioles (2011)
  • Author(s): Hama-Tomioka, Kinoshita H, Nakahata K, Kondo T, Azma T, Kawahito S, Hatakeyama N, Matsuda N
  • Journal Title: Br J Anaesth Volume: 108(1) Pages: 21-9
  • Peer Reviewed
• [Presentation] Cerebral arteriole reactivity through inward rectifier K+ channels Changes during eclampsia (2011)
  • Author(s): 中畑克俊
  • Organizer: 2011 ASA annual meeting
  • Place of Presentation: シカゴ
  • Year and Date: 2011-10-19
• [Presentation] 畑埜義雄NMDA受容体を介する脳微小血管拡張反応における活性酸素とプロポフォールの役割 (2011)
  • Author(s): 中畑克俊、富岡恵子、木下浩之、松田直之、畠山昇
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-20